Evidence map›Paper›PMID 39428674›Full record

ArticleMagnetic resonance in medicine2025

Single-shot echo planar time-resolved imaging for multi-echo functional MRI and distortion-free diffusion imaging.

Zijing Dong, Lawrence L Wald, Jonathan R Polimeni, Fuyixue Wang

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Combined ADC and TMagnetic resonance in medicine · 2026
    Article
  2. TE-aware state analysis and evolution in dynamic network connectivity.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
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  6. Mapping subarachnoid cerebrospinal fluid circulation in the human brain.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Steady-state free precession for TMagnetic resonance in medicine · 2025
    Article
  9. Ultrafast and robustMagnetic resonance in medicine · 2025
    Article
  10. Article
  11. Time-resolved MR fingerprinting for TMagnetic resonance in medicine · 2025
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Zijing DongAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID 0000-0001-9334-0968
Lawrence L WaldAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Jonathan R PolimeniAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Fuyixue WangAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID 0000-0001-8975-2775

Funding

Project 4U19NS123717 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LINNINGER, ANDREAS A · 2021 to 2025
$13.4M
Training and Dissemination CoreP41EB030006 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Susie Yi Huang · 2020 to 2026
$10.9M
fMRI Technologies for Imaging at the Limit of Biological Spatiotemporal Resolution: Administrative SupplementR01EB019437 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI POLIMENI, JONATHAN RIZZO, SETSOMPOP, KAWIN · 2015 to 2024
$5.5M
Advancing fMRI Acquisition through Dissemination of EPTI- An Efficient Distortion-Free Multi-Contrast Imaging TechnologyU24NS129893 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Fuyixue Wang · 2023 to 2026
$2.6M
System Upgrade for Siemens 7T Human MRI SystemS10OD023637 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI WALD, LAWRENCE L · 2017 to 2017
$2.0M
Developing next-generation imaging technologies for in-vivo mesoscale diffusion MRI and microstructure imagingR01EB036507 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Fuyixue Wang · 2025 to 2026
$1.3M
An acquisition and reconstruction framework to enable mesoscale human fMRI on clinical 3 Tesla scannersR01EB033206 · NIBIB · STANFORD UNIVERSITY · PI SETSOMPOP, KAWIN · 2022 to 2022
$853k
Imaging brain-wide subarachnoid and perivascular cerebrospinal fluid flow in aging and Alzheimer's diseaseR00AG083056 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Zijing Dong · 2025 to 2026
$493k
Imaging brain-wide subarachnoid and perivascular cerebrospinal fluid flow in aging and Alzheimer's diseaseK99AG083056 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI DONG, ZIJING · 2023 to 2024
$268k
NIA NIH HHS K99 AG083056NIA NIH HHS R00 AG083056NIBIB NIH HHS P41 EB030006NIBIB NIH HHS R01 EB019437NIBIB NIH HHS R01 EB033206NIBIB NIH HHS R01 EB036507NIH HHS S10 OD023637NINDS NIH HHS U19 NS123717NINDS NIH HHS U24 NS129893
6 · The paper itself

Abstract

purposeTo develop a single-shot SNR-efficient distortion-free multi-echo imaging technique for dynamic imaging applications.

methodsEcho planar time-resolved imaging (EPTI) was first introduced as a multi-shot technique for distortion-free multi-echo imaging. This work aims to develop single-shot EPTI (ss-EPTI) to achieve improved robustness to motion/physiological noise, increased temporal resolution, and higher SNR efficiency. A new spatiotemporal encoding that enables reduced phase-encoding blips and minimized echo spacing under the single-shot regime was developed, which improves sampling efficiency and enhances spatiotemporal correlation in the k-TE space for improved reconstruction. A continuous readout with minimized deadtime was employed to optimize SNR efficiency. Moreover, k-TE partial Fourier and simultaneous multi-slice acquisition were integrated for further acceleration.

resultsss-EPTI provided distortion-free imaging with densely sampled multi-echo images at standard resolutions (e.g., ˜1.25 to 3 mm) in a single-shot. Improved SNR efficiency was observed in ss-EPTI due to improved motion/physiological-noise robustness and efficient continuous readout. Its ability to eliminate dynamic distortions-geometric changes across dynamics due to field changes induced by physiological variations or eddy currents-further improved the data's temporal stability. For multi-echo fMRI, ss-EPTI's multi-echo images recovered signal dropout in short-

conclusionss-EPTI provides SNR-efficient distortion-free multi-echo imaging with comparable temporal resolutions to ss-EPI, offering a new acquisition tool for dynamic imaging.

Indexed as

AlgorithmsBrainEcho-Planar ImagingImage Processing, Computer-AssistedPhantoms, ImagingSignal-To-Noise RatioArtifactsDiffusion Magnetic Resonance ImagingFourier AnalysisHumansMagnetic Resonance ImagingMotiondiffusion MRIdistortion‐freedynamic imagingEPTImulti‐echo fMRIsingle shot

Identifiers

PMID39428674
PMCPMC11680730

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Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.