ArticleDevelopmental medicine and child neurology2025
Cerebellar haemorrhage and atrophy in infants born extremely preterm with intraventricular haemorrhage.
Article in Developmental medicine and child neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Cerebellar hemorrhage with germinal matrix intraventricular hemorrhage: Continuum from fetal to neonatal life.Developmental medicine and child neurology · 2025Article
- Cerebellar haemorrhage and atrophy in infants born extremely preterm with intraventricular haemorrhage.Developmental medicine and child neurology · 2025Article
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Authors and funding
7 authors.
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Abstract
aimTo investigate the impact of cerebellar haemorrhage (CBH) and atrophy in infants born extremely preterm with intraventricular haemorrhage (IVH) on neurodevelopment at 2 years of age.
methodThis retrospective case-control study included infants born at less than 28 weeks' gestation with IVH over a 10-year period. CBH, along with the assessment of cerebellar size, using magnetic resonance imaging, were studied. The impact of injuries on neurodevelopmental outcome at 2 years' corrected age was conducted, using multivariable regression analysis for comprehensive evaluation.
resultsIn a cohort of 103 patients, 69 (67.0%) showed CBH with a median grade of 1 (interquartile range = 0-3). At the corrected age of 2 years, CBH was significantly associated with impaired cognitive and motor outcome. CBH emerged as an independent predictor of poor cognitive and motor development, as well as cerebral palsy. Cerebellar atrophy, affecting 30 (29.1%) infants, was linked to a significantly worse outcome across all domains. Conversely, an increase in cerebellar size was correlated with improved motor development.
interpretationInfants born extremely preterm with IVH and concomitant CBH exhibited significant cognitive and motor impairment. The severity of developmental delay correlated with the grade of CBH. These findings hold potential to support the prediction of long-term outcome and parental counselling.
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