ArticleSignal transduction and targeted therapy2024
Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis.
Article in Signal transduction and targeted therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Utility of intercostal artery perforator flap in granulomatous lobular mastitis: a single-center retrospective study.Gland surgery · 2026Article
- An endocrine microbe immunity framework for granulomatous mastitis toward phenotype-oriented interpretation.iScience · 2026Review
- Development and Internal Validation of a Clinical Data-Based Machine Learning Web Calculator for Predicting Recurrence in Granulomatous Lobular Mastitis: A Multicenter Retrospective Study.European journal of breast health · 2026Article
- Small-incision, point-by-point debridement combined with double-cannula negative-pressure irrigation and drainage for granulomatous mastitis: A single-center retrospective cohort study.The Journal of international medical research · 2026Article
- Therapeutic effects of Tuolitounong decoction on pyroptosis in granulomatous lobular mastitis: evidence from in vitro and in vivo models.Journal of molecular histology · 2026Article
- Distinguishing granulomatous lobular mastitis from breast cancer using a clinical-radiomics nomogram to improve diagnostic accuracy.Frontiers in oncology · 2026Article
- Comparative pangenomics of theFrontiers in microbiology · 2026Article
- Study on the influence of microabscess on the recurrence of granulomatous lobular mastitis and stratified treatment strategies.PloS one · 2026Article
- Cystic Neutrophilic Granulomatous Mastitis in Accessory Breast Tissue: A Case Report.International journal of women's health · 2026Article
- Epidemiology and antimicrobial resistance of pathogens in granulomatous mastitis: A multicenter study in Guangdong, China.iScience · 2025Article
- Article
- Diagnosis of non-puerperal mastitis based on "whole tongue" features: non-invasive biomarker mining and diagnostic model construction.Frontiers in cellular and infection microbiology · 2025Article
- Exploring the interplay of prolactin and bromocriptine on serum markers in granulomatous lobular mastitis.Frontiers in immunology · 2025Article
- Mechanisms of EMT in the immune microenvironment of plasma cell mastitis.Frontiers in immunology · 2025Review
- Idiopathic Granulomatous Mastitis: Immune-Pathogen Imbalance in a Treatment-Resistant Benign Inflammatory Disease.International journal of women's health · 2025Review
- Rat Model of Cystic Neutrophilic Granulomatous Mastitis by Corynebacterium Kroppenstedtii.Journal of inflammation research · 2025Article
- Single-cell RNA sequencing analysis reveals cell landscape and gene signatures associated with granulomatous lobular mastitis.Frontiers in immunology · 2025Article
- Emerging mastitis-associatedFrontiers in cellular and infection microbiology · 2025Article
- Article
- Rat Model of Granulomatous Mastitis.Journal of inflammation research · 2025Article
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Granulomatous lobular mastitis (GLM) is a chronic idiopathic granulomatous mastitis of the mammary gland characterized by significant pain and a high propensity for recurrence, the incidence rate has gradually increased, and has become a serious breast disease that should not be ignored. GLM is highly suspected relative to microbial infections, especially those of Corynebacterium species; however, the mechanisms involved are unclear, and prevention and treatment are difficult. In this study, we demonstrated the pathogenicity of Corynebacterium parakroppenstedtii in GLM using Koch's postulates. Based on the drug sensitization results of C. parakroppenstedtii, and utilizing a retrospective study in conjunction with a comprehensive literature review, we suggested an efficacious, targeted antibiotic treatment strategy for GLM. Subsequently, we identified the pathogenic factor as a new type of glycolipid (named corynekropbactins) secreted by C. parakroppenstedtii. Corynekropbactins may chelate iron, cause the death of mammary cells and other mammary -gland-colonizing bacteria, and increase the levels of inflammatory cytokines. We further analyzed the prevalence of C. parakroppenstedtii infection in patients with GLM. Finally, we suggested that the lipophilicity of C. parakroppenstedtii may be associated with its infection route and proposed a possible model for the development of GLM. This research holds significant implications for the clinical diagnosis and therapeutic management of GLM, offering new insights into targeted treatment approaches.
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