ArticleInternal medicine (Tokyo, Japan)2025
Plasmablastic Lymphoma Complicated with Pure Red Cell Aplasia Caused by T-cell Large Granular Lymphocytic Leukemia.
Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Plasmablastic lymphoma (PBL) is an aggressive subtype of large B-cell lymphoma associated with immunodeficient states, such as HIV and EBV infections, and aging. PBL frequently harbor STAT3 mutations, which are crucial for their development. We herein report a rare case of PBL complicated by T-cell large granular lymphocytic leukemia (T-LGLL) and pure red cell aplasia (PRCA). The patient was treated with six cycles of chemotherapy and developed transfusion-dependent anemia. Large granular lymphocytes and T-cell receptor rearrangement were detected, thus leading to the diagnosis of T-LGLL and PRCA. This is the first documented case of PBL with T-LGLL and PRCA, offering insight into PBL's pathophysiology and the complications of PBL.
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