Evidence map›Paper›PMID 39428456›Full record

ArticleBMC medicine2024

Organic food consumption during pregnancy and symptoms of neurodevelopmental disorders at 8 years of age in the offspring: the Norwegian Mother, Father and Child Cohort Study (MoBa).

Johanne T Instanes, Berit S Solberg, Liv G Kvalvik, Kari Klungsøyr, Maj-Britt R Posserud, Catharina A Hartman, Jan Haavik

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Article in BMC medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Johanne T InstanesDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. Johanne.instanes@uib.no.
Berit S SolbergDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Liv G KvalvikDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Kari KlungsøyrDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Maj-Britt R PosserudDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Catharina A HartmanDepartment of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Jan HaavikDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Funding

the European Union's Horizon 2020 728018
6 · The paper itself

Abstract

backgroundPartially driven by public concerns about modern food production practices, organic food has gained popularity among consumers. However, the impact of organic food consumption during pregnancy on offspring health is scarcely studied. We aimed to investigate the association between maternal intake of organic food during pregnancy and symptoms of attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in offspring at 8 years of age.

methodsThis study was based on the Norwegian Mother, Father and Child Cohort Study (MoBa) and the Medical Birth Registry of Norway (MBRN). The total study sample included 40,707 mother-child pairs (children born 2002-2009). Organic food consumption during pregnancy was assessed by six questions from a food frequency questionnaire in mid-pregnancy (sum score 0-18). Symptoms of ADHD and ASD in the offspring aged 8 years were measured by ADHD (0-54) and ASD (0-39) symptom scores based on the Parent/Teacher Rating Scale for Disruptive Behaviour disorders and the Social Communication Questionnaire. Associations between maternal intake of organic food during pregnancy and symptoms of ADHD and ASD in the offspring were analyzed using regression models with adjustment for covariates such as maternal anxiety and depression, including sibling analysis.

resultsMean ADHD and ASD symptom scores in the offspring differed only slightly by maternal intake of organic food. The covariate-adjusted unstandardized regression coefficient (adjusted(Adj)beta) with 95% confidence interval for the ADHD symptom score with one unit increase in organic food sum score was 0.03 (0.01, 0.05). Similarly, Adjbeta for autism symptom score was 0.07 (0.04, 0.10). For ADHD, the adjusted estimates weakened when adjusting for maternal symptoms of ADHD. The sibling analyses showed no significant results with Adjbeta - 0.07 (- 0.15, 0.01) and - 0.001 (- 0.12, 0.12) for ADHD and ASD outcomes, respectively.

conclusionsWe observed weak positive associations between frequent maternal organic food consumption during pregnancy and offspring ADHD and ASD symptom levels at 8 years of age. This trend weakened or disappeared after adjusting for maternal symptoms of ADHD, and in sibling analyses, suggesting that the associations mainly reflect genetic confounding. Our study indicates that consumption of organic food during pregnancy should neither be considered a risk factor nor protective against symptoms of ADHD and ASD in offspring.

Indexed as

Autism Spectrum DisorderFood, OrganicAdultAttention Deficit Disorder with HyperactivityChildCohort StudiesFemaleHumansMaleNeurodevelopmental DisordersNorwayPregnancyPrenatal Exposure Delayed EffectsSurveys and QuestionnairesAttention deficit disorderAutism spectrum disorderCohort studyFather and Child Cohort StudyMBRNMoBaNeurodevelopmental disordersOrganic foodPrenatal nutritionThe Medical Birth Registry of NorwayThe Norwegian Mother

Identifiers

PMID39428456
PMCPMC11492991

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