Evidence map›Paper›PMID 39428396›Full record

ArticlePediatric research2025

Assessing changes in brain structure in new-onset children with acute lymphoblastic leukemia.

Shu Su, Hua-Qiong Qiu, Lian-Hong Cai, Wei-Feng Hou, Shu-Zhen Huang, Li-Bin Huang, Long Qian, Wei Cui, Yian-Qian Chen, Zhi-Yun Yang and 2 more

Abstract read
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In one paragraph

Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shu Su *Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Hua-Qiong Qiu *Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Lian-Hong Cai *Department of Pediatric, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Wei-Feng HouDepartment of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Shu-Zhen HuangDepartment of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Li-Bin HuangDepartment of Pediatric, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Long QianDepartment of Biomedical Engineering, College of Engineering, Peking University, Beijing, China.
Wei CuiDepartment of Biomedical Engineering, College of Engineering, Peking University, Beijing, China.
Yian-Qian ChenDepartment of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Zhi-Yun YangDepartment of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yan-Lai TangDepartment of Pediatric, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. tangylai@mail.sysu.edu.cn.
Li-Ping LinDepartment of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. linlp5@mail2.sysu.edu.cn.

Funding

Guangdong Basic and Applied Basic Research Foundation, ChinaGuangdong Medical Development FoundationScience and Technology Planning Project of Guangdong Province, ChinaScience, Technology Program of Guangzhou, ChinaShenzhen Fundamental Research ProgramTerry Fox Foundation, CanadaYouth Talent Support Program of Guangdong Provincial Association for Science and Technology
6 · The paper itself

Abstract

backgroundBrain structure injury was presented in acute lymphoblastic leukemia (ALL) after treatment; however, its alterations in new-onset stage are still unclear. We aim to explore white matter (WM) and grey matter (GM) alterations using surface-based morphometry (SBM) and tract-based spatial statistics (TBSS) in new-onset pediatric ALL.

methodsThirty-five ALL and 33 typically developing (TD) children were prospectively recruited and underwent three-dimensional T1-weighted and diffusion tensor (DTI) imaging. DTI metrics, cortical GM features, and deep GM nuclei volume were compared between groups differences.

resultsIn ALL, the only increased FA in the body of corpus callosum (P

conclusionWidespread brain structural abnormalities were found in new-onset pediatric ALL, which suggest disease itself can cause brain structural injury. IMPACT: This study revealed the altered white matter integrity and gray matter morphology characteristics in childhood acute lymphoblastic leukemia on new-onset stage. It is suggested that there may be structural impairment before chemotherapy. MRI is a sensitive way for early detection on brain structural damage in childhood acute lymphoblastic leukemia.

Indexed as

BrainGray MatterPrecursor Cell Lymphoblastic Leukemia-LymphomaWhite MatterAdolescentCase-Control StudiesChildChild, PreschoolDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleProspective Studies

Identifiers

PMID39428396

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.