Evidence map›Paper›PMID 39428395›Full record

ArticleNature communications2024

Joint subarray acoustic tweezers enable controllable cell translation, rotation, and deformation.

Liang Shen, Zhenhua Tian, Kaichun Yang, Joseph Rich, Jianping Xia, Neil Upreti, Jinxin Zhang, Chuyi Chen, Nanjing Hao, Zhichao Pei and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  9. Spin-Orbit Angular Momentum Conversion in Coupled Nonparaxial Bessel Acoustic Vortices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liang ShenDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.
Zhenhua TianDepartment of Mechanical Engineering, Virginia Polytechnical Institute and State University, Blacksburg, VA, USA. tianz@vt.edu.ORCID 0000-0002-1903-5604
Kaichun YangDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.
Joseph RichDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Jianping XiaDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.ORCID 0000-0001-9902-0228
Neil UpretiDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.ORCID 0000-0002-0751-8174
Jinxin ZhangDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.
Chuyi ChenDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.
Nanjing HaoDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.ORCID 0000-0003-3808-7941
Zhichao PeiDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.
Tony Jun HuangDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA. tony.huang@duke.edu.ORCID 0000-0003-1205-3313

Funding

Development of a multifunctional, acoustofluidic 3D bioprinter with single-cell resolutionR01GM144417 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Zhenhua Tian · 2022 to 2026
$1.8M
National Science Foundation (NSF) 2139754National Science Foundation (NSF) CMMI-2243771National Science Foundation (NSF) CMMI-2340016U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01GM144417
6 · The paper itself

Abstract

Contactless microscale tweezers are highly effective tools for manipulating, patterning, and assembling bioparticles. However, current tweezers are limited in their ability to comprehensively manipulate bioparticles, providing only partial control over the six fundamental motions (three translational and three rotational motions). This study presents a joint subarray acoustic tweezers platform that leverages acoustic radiation force and viscous torque to control the six fundamental motions of single bioparticles. This breakthrough is significant as our manipulation mechanism allows for controlling the three translational and three rotational motions of single cells, as well as enabling complex manipulation that combines controlled translational and rotational motions. Moreover, our tweezers can gradually increase the load on an acoustically trapped cell to achieve controllable cell deformation critical for characterizing cell mechanical properties. Furthermore, our platform allows for three-dimensional (3D) imaging of bioparticles without using complex confocal microscopy by rotating bioparticles with acoustic tweezers and taking images of each orientation using a standard microscope. With these capabilities, we anticipate the JSAT platform to play a pivotal role in various applications, including 3D imaging, tissue engineering, disease diagnostics, and drug testing.

Indexed as

AcousticsAnimalsHumansImaging, Three-DimensionalOptical TweezersRotation

Identifiers

PMID39428395
PMCPMC11491459

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.