ArticleInternational dental journal2025
GLS as a Key Cuproptosis-Related Gene in Periodontitis: Insights from Single-Cell RNA Sequencing.
Article in International dental journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Cuproptosis in inflammation and cancer: molecular mechanisms and therapeutic targets.Molecular cancer · 2026Review
- Cuproptosis: Biomarkers, Mechanisms and Treatments in Diseases.Molecules (Basel, Switzerland) · 2026Review
- Identification of cuproptosis-related genes in chronic apical periodontitis based on bulk and single-cell RNA sequencing analyses and experimental validation.Frontiers in immunology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study is to investigate the role of cuproptosis-related genes (CRGs) in periodontitis using an integrative approach that combines single-cell RNA sequencing (scRNA-seq) and bioinformatic analyses. The study aims to elucidate the connection between copper-induced cell death (cuproptosis) and periodontitis, a prevalent chronic inflammatory oral disease that leads to tooth-supporting tissue damage and eventual tooth loss.
methodsDifferentially expressed genes (DEGs) were identified from the GSE10334 dataset, leading to the discovery of 14 differentially expressed CRGs associated with periodontitis. Subsequent application of least absolute shrinkage and selection operator (LASSO) regression and logistic regression analysis pinpointed three key CRGs: MTF1, GLS, and DLST. Single-cell sequencing data analysis was further conducted to explore the expression patterns of these genes, particularly GLS, within immune cells and their association with the immune cell network in periodontal tissues.
resultsThe study revealed that GLS is widely expressed in immune cells and is closely linked to the complex immune cell interactions within periodontal tissues. This finding underscores GLS as a potential therapeutic target in the context of periodontitis, associated with cuproptosis. The integration of single-cell sequencing data highlighted the significant role of cuproptosis in the diversity and complexity of periodontitis pathogenesis.
conclusionThis research advances the understanding of the crosstalk between periodontitis and cuproptosis, emphasising the role of CRGs, especially GLS, in periodontitis. Furthermore, this study on cuproptosis may contribute to future diagnostic and therapeutic strategies for periodontitis.
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