Evidence map›Paper›PMID 39427552›Full record

ArticleTransfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis2024

Genetic determinants of plasma testosterone in male blood donors are associated with altered red blood cell characteristics and survival in cold storage and after transfusion.

Fang Fang, Nareg H Roubinian, Scott-Wesley Bean, Cassie Kemmler, Grier G Page, Tamir Kanias

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Article in Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Fang FangGenOmics and Translational Research Center, RTI International, NC, USA.
Nareg H RoubinianVitalant Research Institute, San Francisco, CA, USA; Kaiser Permanente Northern California Division of Research, Pleasanton, CA, USA; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Scott-Wesley BeanVitalant Research Institute, Denver, CO, USA.
Cassie KemmlerVitalant Research Institute, Denver, CO, USA.
Grier G PageAnalytics Program and RTI Fellow Program, RTI International, Atlanta, GA, USA.
Tamir KaniasVitalant Research Institute, Denver, CO, USA; Department of Pathology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA. Electronic address: tkanias@vitalant.org.

Funding

Effects of blood conservation and donor characteristics on transfused patient outcomes in a large community hospital networkR01HL126130 · NHLBI · VITALANT · PI ROUBINIAN, NAREG · 2016 to 2019
$1.9M
Effect of blood donor sex and inter-individual variability in plasma testosterone on the transfusion effectiveness and hemostatic potential of red blood cells and plateletsR56HL134653 · NHLBI · VITALANT · PI KANIAS, TAMIR · 2023 to 2023
$739k
NHLBI NIH HHS R01 HL126130NHLBI NIH HHS R56 HL134653
6 · The paper itself

Abstract

Genetic mutations in genes regulating plasma testosterone in men may interfere with effective erythropoiesis, and may result in red blood cell (RBC) dysfunction and hemolysis. The aim of this study was to identify genetic polymorphisms in male donors that regulate plasma testosterone and impact RBC survival in cold storage and after transfusion. We evaluated nine single nucleotide polymorphisms (SNPs) previously reported to be associated with circulating testosterone in male plasma. These SNPs were linked with donor-component-recipient databases (NIH REDS program) to determine SNP associations with donor RBC hematological indices, osmotic and oxidative hemolysis, and RBC transfusion effectiveness defined as adjusted hemoglobin increments (delta hemoglobin, ΔHb) following a single RBC unit transfusion. Four of the nine testosterone SNPs were located on the X chromosome, of which two (rs7057002, rs73629199) were significantly associated with reduced hemoglobin increments (0.2 and 0.3 g/dL, respectively) compared with reference alleles in transfused recipients. Seven of the nine testosterone SNPs were associated with significant changes in RBC susceptibility to osmotic hemolysis including a missense mutation in the major plasma carrier of testosterone (SHBG, rs6259), and four SNPs with changes in oxidative hemolysis. Four SNPs were associated with decreased RBC count, hemoglobin, and hematocrit. Ancestry/ethnicity-specific (African and Hispanic) associations were observed between two SNPs (rs7057002, rs7879462) and oxidative hemolysis. Genetic determinants of plasma testosterone in male donors significantly impact the quality and transfusion effectiveness of cold stored RBCs. Testosterone SNPs associated with decreased RBC transfusion effectiveness may have clinical implications and warrant further revaluation.

Indexed as

Blood DonorsErythrocytesPolymorphism, Single NucleotideTestosteroneAdultBlood PreservationHumansMaleTestosteroneBlood donorsHemolysisRed blood cellsSingle nucleotide polymorphismsTestosteroneTransfusion effectiveness

Identifiers

PMID39427552
PMCPMC11641673

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.