Evidence map›Paper›PMID 39427414›Full record

ArticleEBioMedicine2024

Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype.

Manukumar Honnayakanahalli Marichannegowda, Saini Setua, Meera Bose, Eric Sanders-Buell, David King, Michelle Zemil, Lindsay Wieczorek, Felisa Diaz-Mendez, Nicolas Chomont, Rasmi Thomas and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Distinct memory CD4ASM case reports · 2025
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Manukumar Honnayakanahalli MarichannegowdaInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Saini SetuaInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Meera BoseU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, MD, USA.
Eric Sanders-BuellU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, MD, USA.
David KingThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, MD, USA.
Michelle ZemilU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, MD, USA.
Lindsay WieczorekU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, MD, USA.
Felisa Diaz-MendezInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Nicolas ChomontCentre de Recherche du CHUM and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montréal, Canada.
Rasmi ThomasCenter for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Leilani FranciscoU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, MD, USA.
Leigh Anne EllerU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, MD, USA.
Victoria R PolonisU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Sodsai TovanabutraU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, MD, USA.
Alonso HerediaInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Yutaka TagayaInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Nelson L MichaelCenter for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Merlin L RobbU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, MD, USA.
Hongshuo SongInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: hongshuo.song@ihv.umaryland.edu.

Funding

Quantification of the HIV-1 Reservoir by Immuno-PCRR01AI120008 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI HEREDIA, ALONSO, LICHTERFELD, MATHIAS · 2015 to 2019
$1.9M
Escape by Shifting: Viral Entry Tropism Shift as an Evolutionary Mechanism of Immune EvasionR01AI181601 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI Hongshuo Song · 2024 to 2026
$1.2M
Genetic imprints of therapeutic Ad26/MVA mosaic vaccine in rebound HIV-1 genome from acutely treated individualsR21AI147893 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI SONG, HONGSHUO · 2019 to 2020
$441k
NIAID NIH HHS R01 AI120008NIAID NIH HHS R01 AI181601NIAID NIH HHS R21 AI147893
6 · The paper itself

Abstract

backgroundNearly all transmitted/founder (T/F) HIV-1 are CCR5 (R5)-tropic. While previous evidence suggested that CXCR4 (X4)-tropic HIV-1 are transmissible, virus detection and characterization were not at the earliest stages of acute infection.

methodsWe identified an X4-tropic T/F HIV-1 in a participant (40700) in the RV217 acute infection cohort. Coreceptor usage was determined in TZM-bl cell line, NP-2 cell lines, and primary CD4

findingsParticipant 40700 was infected by an X4 tropic HIV-1 without CCR5 using ability. This participant experienced significantly faster CD4 depletion compared to R5 virus infected individuals in the same cohort. Naïve and central memory (CM) CD4 subsets declined faster than effector memory (EM) and transitional memory (TM) subsets. All CD4 subsets, including the naïve, were productively infected. Increased CD4

interpretationX4-tropic HIV-1 is transmissible through mucosal route in people with wild-type CCR5 genotype. The CD4 subset tropism of HIV-1 may be an important determinant for HIV-1 transmissibility and virulence.

fundingInstitute of Human Virology, National Institutes of Health, Henry M. Jackson Foundation for the Advancement of Military Medicine.

Indexed as

CD4-Positive T-LymphocytesGenotypeHIV-1HIV InfectionsReceptors, CCR5Receptors, CXCR4Viral LoadViral TropismAdultCell LineHumansMaleMucous MembraneVirulenceCCR5 protein, humanCXCR4 protein, humanReceptors, CCR5Receptors, CXCR4CD4 subsetCXCR4HIV-1Mucosal transmissionPathogenesis

Identifiers

PMID39427414
PMCPMC11533037

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.