Evidence map›Paper›PMID 39427160›Full record

ArticleJournal of neuroinflammation2024

Anti-CD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8

Zhangying Chen, Kacie P Ford, Mecca B A R Islam, Hanxiao Wan, Hyebin Han, Abhirami Ramakrishnan, Ryan J Brown, Veronica Villanueva, Yidan Wang, Booker T Davis and 4 more

Abstract read
In one paragraph

Article in Journal of neuroinflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Zhangying ChenDepartment of Surgery, Division of Trauma and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. jenniechen2024@u.northwestern.edu.
Kacie P FordDepartment of Surgery, Division of Trauma and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Mecca B A R IslamDepartment of Surgery, Division of Trauma and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Hanxiao WanDriskill Graduate Program in Life Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Hyebin HanDepartment of Surgery, Division of Trauma and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Abhirami RamakrishnanDriskill Graduate Program in Life Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Ryan J BrownDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Veronica VillanuevaDepartment of Surgery, Division of Trauma and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Yidan WangDriskill Graduate Program in Life Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Booker T DavisDepartment of Surgery, Division of Trauma and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Craig WeissDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Weiguo CuiDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
David GateThe Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Steven J SchwulstDepartment of Surgery, Division of Trauma and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
PREDOCTORAL AND POSTDOCTORAL TRAINING PROGRAM IN AGING AND DEMENTIAT32AG020506 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR, SANDRA WEINTRAUB · 2002 to 2026
$9.9M
Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Trauma, the gut, and the brain: the gut microbiota-microglia axis in traumatic brain injuryR01NS127865 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI STEVEN J SCHWULST · 2022 to 2026
$3.0M
The Young Gut Microbiome: A Fountain of Youth for Brain Injury in the Aged?RF1NS135652 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHWULST, STEVEN J · 2023 to 2024
$2.5M
The 10x Chromium System for High-Throughput Single Cell GenomicsS10OD025120 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WANG, XINKUN · 2019 to 2019
$79k
NCI NIH HHS P30 CA060553NIA NIH HHS T32 AG020506NIGMS NIH HHS T32 GM080202NIH HHS S10 OD025120NINDS NIH HHS R01 NS127865NINDS NIH HHS RF1 NS135652
6 · The paper itself

Abstract

Patients aged 65 years and older account for an increasing proportion of patients with traumatic brain injury (TBI). Older TBI patients experience increased morbidity and mortality compared to their younger counterparts. Our prior data demonstrated that by blocking α4 integrin, anti-CD49d antibody (aCD49d Ab) abrogates CD8

Indexed as

Brain Injuries, TraumaticCD8-Positive T-LymphocytesMice, Inbred C57BLAgingAnimalsCytokinesInflammationMaleMiceCytokines

Identifiers

PMID39427160
PMCPMC11491007

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.