Evidence map›Paper›PMID 39427100›Full record

ArticlePediatric research2025

Abdominal obesity in youth: the associations of plasma Lysophophatidylcholine concentrations with insulin resistance.

Xinyi Zhang, Huiying Liu, Chenyu Li, Ying Wei, Xuan Kan, Xiaoxiao Liu, Xinyi Han, Zhenghao Zhao, Tianfeng An, Zhong-Ze Fang and 3 more

Abstract read
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In one paragraph

Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xinyi Zhang *Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China.
Huiying Liu *Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, and the Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
Chenyu LiDepartment of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China.
Ying WeiDepartment of Pediatrics, Tianjin Medical University General Hospital, Tianjin, China.
Xuan KanDepartment of Pediatrics, Tianjin Medical University General Hospital, Tianjin, China.
Xiaoxiao LiuDepartment of Pediatrics, Tianjin Medical University General Hospital, Tianjin, China.
Xinyi HanDepartment of Pediatrics, Tianjin Medical University General Hospital, Tianjin, China.
Zhenghao ZhaoDepartment of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China.
Tianfeng AnDepartment of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China.
Zhong-Ze FangDepartment of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China.
Shifeng MaDepartment of Pediatrics, Tianjin Medical University General Hospital, Tianjin, China. mashf2010@163.com.
Rongxiu ZhengDepartment of Pediatrics, Tianjin Medical University General Hospital, Tianjin, China. rzheng@tmu.edu.cn.
Jing LiTianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China. Lijing_ph@tmu.edu.cn.

Funding

General hospital Clinical research projectNational Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaTianjin Key Medical Discipline (Specialty) Construction ProjectTianjin Science and Technology Plan Project
6 · The paper itself

Abstract

backgroudThis study aimed to explore the associations of lysophosphatidylcholines (LPCs) with insulin resistance (IR) and abdominal obesity among children and adolescents.

methodsA cross-sectional study was conducted on 612 young individuals, aged 7 to 18 years in Tianjin City, China. LC-MS metabolomic analysis was used to measure LPCs levels. The Homeostasis Model Assessment was used to estimate IR. Waist circumference measurements were used to assess abdominal obesity. Logistic regression models were employed to explore the relationships between LPCs and IR and abdominal obesity. Mediation analyses were performed to analyze whether LPCs affected IR through abdominal obesity.

resultsCompared to their counterparts, five specific LPCs were significantly different in youth with IR. The levels of LPC 24:0 and 26:0 were significantly associated with IR after adjustment. Both decreased levels of LPC 24:0 and 26:0 associated with the increased risks of IR (OR: 0.64, 95%CI: 0.38-0.95; OR: 0.66, 95%CI: 0.40-1.00), and the ORs for abdominal obesity were 0.68 (95%CI: 0.38-1.00) and 0.51 (95%CI: 0.28-0.90), respectively. Mediation analysis indicated that abdominal obesity mediated the association between LPC 26:0 and IR, with a total effect (c) of -0.109 (P < 0.05), a direct effect (c') of -0.055 (P > 0.05), and an indirect effect through obesity (a × b) path with "a" of -0.125 (P < 0.05) and "b" of 0.426 (P < 0.05).

conclusionOverall findings suggest that decreased levels of LPC 24:0 and 26:0 were associated with increased risks of IR and abdominal obesity. Importantly, addressing abdominal obesity may mediate the impact of IR driven by LPC 26:0.

Indexed as

Insulin ResistanceLysophosphatidylcholinesObesity, AbdominalPediatric ObesityAdolescentBiomarkersChildChinaCross-Sectional StudiesFemaleHumansLogistic ModelsMaleMetabolomicsRisk FactorsWaist CircumferenceBiomarkersLysophosphatidylcholines

Identifiers

PMID39427100

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.