Evidence map›Paper›PMID 39427049›Full record

ArticleClinical rheumatology2024

Characteristics associated with anterior ischemic optic neuropathy (AION) in giant cell arteritis (GCA).

Jenna L Thomason, Ingeborg Sacksen, R Eugene Zierler, Courtney E Francis, P Scott Pollock, Alison M Bays

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Article in Clinical rheumatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jenna L ThomasonDivision of Rheumatology, Department of Medicine, University of Washington, 1959 NE Pacific St Health Sciences Bldg BB561 Campus Box 356428, Seattle, WA, 98195, USA.
Ingeborg SacksenDivision of Rheumatology, Department of Medicine, University of Washington, 1959 NE Pacific St Health Sciences Bldg BB561 Campus Box 356428, Seattle, WA, 98195, USA.
R Eugene ZierlerDivision of Vascular Surgery, Department of Surgery, University of Washington, Seattle, WA, USA.
Courtney E FrancisDepartment of Ophthalmology, University of Washington, Seattle, WA, USA.
P Scott PollockDivision of Rheumatology, Department of Medicine, University of Washington, 1959 NE Pacific St Health Sciences Bldg BB561 Campus Box 356428, Seattle, WA, 98195, USA.
Alison M BaysDivision of Rheumatology, Department of Medicine, University of Washington, 1959 NE Pacific St Health Sciences Bldg BB561 Campus Box 356428, Seattle, WA, 98195, USA. alisonmb@uw.edu.ORCID http://orcid.org/0000-0002-7193-6303

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveGiant cell arteritis (GCA) is the most common vasculitis and can result in blindness due to anterior ischemic optic neuropathy (AION). Little is known about which patients with GCA are at higher risk of AION.  We did a retrospective chart review to compare demographics, past medical history, labs and imaging of GCA patients with and without AION.

methodsAll patients at the University of Washington who were diagnosed with GCA by a rheumatologist, had a vascular ultrasound and met classification criteria for GCA were included. AION was diagnosed by an ophthalmologist. To compare demographics, symptoms, presentation imaging and lab findings, we used Pearson Chi-square, Fisher's exact test and t-tests to compare GCA patients with and without AION.

results91 patients with GCA without vision loss were compared to 15 patients with GCA and AION. The AION group had significantly more men (p=0.03) and elevated C-reactive protein (CRP) as compared to the non-AION group (p = 0.04). Rates of hypertension, smoking, erythrocyte sedimentation rate (ESR) and classification scores were similar. Vascular ultrasound showed similar rates of small and large vessel vasculitis, but the AION group had higher halo scores, with the AION group having a mean score of 5 and patients with GCA and without AION having a mean score of 3 (p < 0.01).

conclusionsOlder men with GCA and more than three halos on vascular ultrasound imaging of GC may be at higher risk of AION. Key Points • This is the first paper to incorporate the use of vascular ultrasound in comparing patients with anterior ischemic optic neuropathy (AION) to those without giant cell arteritis (GCA). • Male sex is associated with AION despite GCA being more common in women. • Older age and higher CRP are associated with AION. • GCA patients with AION had a higher halo score than GCA patients without AION.

Indexed as

Giant Cell ArteritisOptic Neuropathy, IschemicAgedAged, 80 and overBlood SedimentationC-Reactive ProteinFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsUltrasonographyC-Reactive Protein

Identifiers

PMID39427049

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.