ArticleChest2025
Comparative Effectiveness of Albumin vs No Albumin on Renal Replacement Therapy and Mortality in Patients With Septic Shock and Renal Impairment.
Article in Chest, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Review
- Association between nadir albumin concentration and mortality in pediatric patients undergoing postcardiotomy extracorporeal membrane oxygenation.Translational pediatrics · 2026Article
- Early use of albumin may increase the risk of sepsis-associated acute kidney injury in sepsis patients: a target trial emulation.Military Medical Research · 2025Article
- Association between lactate-to-albumin ratio and 28-day ICU mortality in pediatric severe pneumonia patients.PloS one · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundAlbumin infusions may be renally protective or harmful in patients with septic shock who have kidney impairment. This can affect the need for renal replacement therapy (RRT) and in-hospital mortality. RESEARCH QUESTION: Does the early use of albumin mitigate the need for RRT or in-hospital mortality in patients with septic shock and kidney impairment on hospital admission? STUDY DESIGN AND
methodsThis was a retrospective multicenter inverse probability-of-treatment weighted cohort study conducted in 220 geographically diverse community and teaching hospitals across the United States. Adult patients were included if they had septic shock and kidney impairment on hospital admission. Patients were categorized as those who received albumin (within 24 hours of admission) or no albumin during hospitalization. Proportion of patients with RRT or in-hospital mortality were compared between groups.
resultsOf the 9,988 patients included in the final cohort, 7,929 did not receive albumin and 2,059 received albumin. Patients had a mean ± SD age of 67.8 ± 14.8 years, 46.3% were female, and the mean estimated glomerular filtration rate was 32 ± 12 mL/min/1.73 m
interpretationIn patients with septic shock and kidney impairment on hospital admission, early albumin use may be associated with an increased composite outcome of RRT or in-hospital mortality. This increased risk is most associated with hyperoncotic albumin rather than iso-oncotic albumin.
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