Evidence map›Paper›PMID 39426603›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2024

Association between coronary microvascular dysfunction and exercise capacity in dilated cardiomyopathy.

Abhishek Dattani, Benjamin A Marrow, Gaurav S Gulsin, Jian L Yeo, Amitha Puranik, Emer M Brady, David Adlam, Anvesha Singh, Mohammedimran M Ansari, Jayanth R Arnold and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. [Preliminary Study of Dilated Cardiomyopathy at a High Altitude Based on Cardiac Magnetic Resonance Feature Tracking].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Abhishek DattaniDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health and Care Research Leicester Biomedical Research Centre, Leicester, UK.
Benjamin A MarrowDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health and Care Research Leicester Biomedical Research Centre, Leicester, UK.
Gaurav S GulsinDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health and Care Research Leicester Biomedical Research Centre, Leicester, UK.
Jian L YeoDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health and Care Research Leicester Biomedical Research Centre, Leicester, UK.
Amitha PuranikDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health and Care Research Leicester Biomedical Research Centre, Leicester, UK.
Emer M BradyDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health and Care Research Leicester Biomedical Research Centre, Leicester, UK.
David AdlamDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health and Care Research Leicester Biomedical Research Centre, Leicester, UK.
Anvesha SinghDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health and Care Research Leicester Biomedical Research Centre, Leicester, UK.
Mohammedimran M AnsariUniversity Hospitals of Leicester NHS Trust, Leicester, UK.
Jayanth R ArnoldDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health and Care Research Leicester Biomedical Research Centre, Leicester, UK.
Hui XueNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Peter KellmanNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
James S WareNational Heart and Lung Institute & MRC Laboratory of Medical Sciences, Imperial College London, London, UK.
Gerry P McCannDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health and Care Research Leicester Biomedical Research Centre, Leicester, UK. Electronic address: gpm12@leicester.ac.uk.

Funding

NIHR RP-2017-08-ST2-007
6 · The paper itself

Abstract

backgroundAerobic exercise capacity is an independent predictor of mortality in dilated cardiomyopathy (DCM), but the central mechanisms contributing to exercise intolerance in DCM are unknown. The aim of this study was to characterize coronary microvascular function in DCM and determine if cardiovascular magnetic resonance (CMR) measures are associated with aerobic exercise capacity.

methodsProspective case-control comparison of adults with DCM and matched controls. Adenosine-stress perfusion CMR to assess cardiac structure, function and automated inline myocardial blood flow quantification, and cardiopulmonary exercise testing to determine peak VO

resultsSixty-six patients with DCM (mean age 61 years, 47 male) were propensity-matched to 66 controls (mean age 59 years, 47 male) based on age, sex, body mass index, and diabetes. DCM patients had markedly lower peak VO

conclusionIn comparison to controls, DCM patients have lower stress myocardial blood flow and MPR. In DCM, MPR, LV ejection fraction, and fibrosis are independently associated with aerobic exercise capacity.

Indexed as

Cardiomyopathy, DilatedCoronary CirculationExercise TestExercise ToleranceMicrocirculationMyocardial Perfusion ImagingOxygen ConsumptionPredictive Value of TestsVentricular Function, LeftAgedCase-Control StudiesCoronary VesselsFemaleFibrosisHumansMagnetic Resonance Imaging, CineVasodilator AgentsCardiovascular magnetic resonanceDilated cardiomyopathyExercise capacityMyocardial perfusion reserve

Identifiers

PMID39426603
PMCPMC11647499

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.