Evidence map›Paper›PMID 39426568›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2024

Analysis of DNA Methylation in Gliomas: Assessment of Preanalytical Variables.

Karol Bomsztyk, Daniel Mar, Oleg Denisenko, Suzanne Powell, Monika Vishnoi, Zheng Yin, Jennifer Delegard, Caroline Hadley, Nitin Tandon, Akash J Patel and 4 more

Abstract read
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Karol BomsztykUW Medicine South Lake Union, University of Washington, Seattle, Washington; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington; Matchstick Technologies, Inc, Kirkland, Washington. Electronic address: karolb@uw.edu.
Daniel MarUW Medicine South Lake Union, University of Washington, Seattle, Washington; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington.
Oleg DenisenkoUW Medicine South Lake Union, University of Washington, Seattle, Washington.
Suzanne PowellDepartment of Neuropathology, Houston Methodist Hospital, Houston, Texas.
Monika VishnoiDepartment of Neurosurgery, Houston Methodist Research Institute, Houston, Texas.
Zheng YinDepartment of Systems Medicine and Bioengineering, Houston Methodist Neil Cancer Center, Houston, Texas.
Jennifer DelegardDepartment of Neurological Surgery, University of Washington, Seattle, Washington.
Caroline HadleyDepartment of Neurosurgery, University of New Mexico, Albuquerque, New Mexico.
Nitin TandonDepartment of Neurosurgery, McGovern Medical School at UT Health, Houston, Texas.
Akash J PatelDepartment of Neurosurgery, Baylor College of Medicine, Houston, Texas.
Anoop P PatelDepartment of Neurosurgery, Duke University, Durham, North Carolina.
Richard G EllenbogenDepartment of Neurological Surgery, University of Washington, Seattle, Washington.
Rohan RamakrishnaDepartment of Neurological Surgery, Weill Cornell Medicine, New York, New York.
Robert C RostomilyDepartment of Neurosurgery, Houston Methodist Research Institute, Houston, Texas; Department of Neurological Surgery, University of Washington, Seattle, Washington; Department of Neurological Surgery, Weill Cornell Medicine, New York, New York.

Funding

PIXUL-FFPE: High throughput platform for chromatin and DNA sample preparation from formalin fixed paraffin embedded (FFPE) tissue samples- supplement application.R42HG010855 · NHGRI · MATCHSTICK TECHNOLOGIES, INC. · PI BOMSZTYK, KAROL · 2019 to 2022
$2.4M
Influence of Pre-Analytical Factors in Globlastoma MGMT Promoter Methylation Biomarker AssayU01CA246503 · NCI · UNIVERSITY OF WASHINGTON · PI BOMSZTYK, KAROL, ROSTOMILY, ROBERT C · 2020 to 2024
$2.0M
NCI NIH HHS U01 CA246503NHGRI NIH HHS R42 HG010855
6 · The paper itself

Abstract

Precision oncology is driven by biomarkers. For glioblastoma multiforme (GBM), the most common malignant adult primary brain tumor, O

Indexed as

Brain NeoplasmsDNA MethylationDNA Modification MethylasesDNA Repair EnzymesGlioblastomaPromoter Regions, GeneticTumor Suppressor ProteinsBiomarkers, TumorFemaleGliomaHumansMaleSpecimen HandlingBiomarkers, TumorDNA Modification MethylasesDNA Repair EnzymesMGMT protein, humanTumor Suppressor ProteinsCryoGridDNA methylationglioblastomaMGMTPIXULpreanalytical variables

Identifiers

PMID39426568
PMCPMC11709230

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.