Evidence map›Paper›PMID 39426329›Full record

ArticleParkinsonism & related disorders2024

Taxonomic intestinal microbiota differences in Lewy body spectrum disease and cohabitant controls.

Levi M Teigen, Stuart J McCarter, Zachary Ziegert, Christopher Staley, Kiera M Grant, Vinod K Gupta, Xiaowei Zhao, Erik K St Louis, Kejal Kantarci, Val J Lowe and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Levi M TeigenDepartment of Food Science and Nutrition, University of Minnesota, St. Paul, MN, 55108, USA. Electronic address: teige027@umn.edu.
Stuart J McCarterDepartment of Neurology, Mayo Clinic, Rochester, MN, 55905, USA; Center for Sleep Medicine, Mayo Clinic, Rochester, MN, 55905, USA.
Zachary ZiegertDepartment of Surgery, School of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA.
Christopher StaleyDepartment of Surgery, School of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA.
Kiera M GrantDepartment of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, 55905, USA.
Vinod K GuptaMicrobiomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, 55905, USA.
Xiaowei ZhaoBioinformatics and Computational Biology Program, University of Minnesota, Rochester, MN, 55904, USA.
Erik K St LouisDepartment of Neurology, Mayo Clinic, Rochester, MN, 55905, USA; Center for Sleep Medicine, Mayo Clinic, Rochester, MN, 55905, USA.
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Leah K ForsbergDepartment of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Rodolfo SavicaDepartment of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Vijay K RamananDepartment of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
David T JonesDepartment of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Jaeyun SungMicrobiomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, 55905, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Rochester, MN, 55904, USA.
Alexander KhorutsDivision of Gastroenterology, Department of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN, 55905, USA; Center for Sleep Medicine, Mayo Clinic, Rochester, MN, 55905, USA.
Owen A RossDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.

Funding

Project: Predicting PhenoconversionU19AG071754 · NIA · WASHINGTON UNIVERSITY · PI Ronald Postuma · 2021 to 2026
$41.2M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2019 to 2026
$33.5M
Longitudinal Imaging Biomarkers of Prodromal DLBU01NS100620 · NINDS · MAYO CLINIC ROCHESTER · PI Bradley F Boeve, KEJAL KANTARCI · 2017 to 2026
$19.2M
Neuroprotective Treatment Trial Planning in REM Sleep Behavior DisorderR34AG056639 · NIA · WASHINGTON UNIVERSITY · PI BOEVE, BRADLEY F, JU, YO-EL S · 2018 to 2019
$1.2M
NIA NIH HHS P30 AG062677NIA NIH HHS R34 AG056639NIA NIH HHS U19 AG071754NINDS NIH HHS U01 NS100620
6 · The paper itself

Abstract

backgroundMicrobial dysbiosis has been reported to contribute to development of neurodegenerative diseases, however, there is a need to identify causative/prognostic indicators.

objectivesTo comparatively analyze gut microbiome composition in symptomatic LBD (dementia/mild cognitive impairment), iRBD, and cohabiting controls without LBD or iRBD.

methods16S rRNA amplicon sequencing was performed in 38 cases (27 LBD, 11 iRBD) and 39 cohabitant controls. 19 non-cohabitant healthy controls (HCs) were also included to contrast differences between cohabitant cases and controls.

resultsMicrobiome composition of cohabitant controls and LBD and iRBD cases were strikingly similar. No differences were observed between LBD, and iRBD only showed reduced Bacteroides, compared with cohabitant controls. There were several taxonomic differences in gut microbiome composition between non-cohabitant HCs and cases.

conclusionsMinimal microbiome differences were observed between iRBD or LBD cases and cohabitant controls. These findings underscore the importance of using cohabiting controls in future gut microbiome studies.

Indexed as

Gastrointestinal MicrobiomeLewy Body DiseaseAgedBacteriaBiodiversityCase-Control StudiesFecesFemaleHumansMaleMiddle AgedRNA, Ribosomal, 16SRNA, Ribosomal, 16S

Identifiers

PMID39426329
PMCPMC11614677

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.