Evidence map›Paper›PMID 39425879›Full record

ArticleBiological trace element research2025

Kolaviron: a Bioflavonoid from Seed Extract of Garcinia kola Attenuates Chromium (VI)-Induced Gut Dysfunction and Oxidative Damage in Drosophila melanogaster.

Onaara Peter Ashaolu, Olugbenga Adeola Odukanmi, Adeola Temitope Salami, Amos Olalekan Abolaji, Samuel Babafemi Olaleye

Abstract read
PubMed Publisher
In one paragraph

Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Onaara Peter AshaoluGastrointestinal Secretion and Inflammation Research Unit, Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Olugbenga Adeola OdukanmiGastrointestinal Secretion and Inflammation Research Unit, Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Adeola Temitope SalamiGastrointestinal Secretion and Inflammation Research Unit, Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Amos Olalekan AbolajiDrosophila Laboratory, Molecular Drug Metabolism and Toxicology Unit, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria. amos_abolaji@yahoo.com.
Samuel Babafemi OlaleyeGastrointestinal Secretion and Inflammation Research Unit, Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria. sbolaleye@gmail.com.

Funding

International Centre for Genetic Engineering and Biotechnology CRP/ NGA18-02
6 · The paper itself

Abstract

Hexavalent chromium [Cr(VI)] is of public health significance due to its toxicity and carcinogenic effects. Kolaviron, a bio-flavonoid fraction from Garcinia kola seed, has been reported to possess gastroprotective and antioxidative properties. We hypothesize that Kolaviron-fortified diet will attenuate chromium (VI)-induced gut dysfunction and oxidative damage in Drosophila melanogaster. We exposed D. melanogaster (Oregon strain of 1-3 days old of both male and female) to a 1.0 mg/kg diet of chromium (VI), with or without Kolaviron (100 mg/kg diet) orally for 5 days. We evaluated markers of oxidative stress (total peroxide and protein carbonyl), antioxidative status (total thiols (T-SH), non-protein thiols (NP-SH), and catalase), and inflammatory (nitric oxide (nitrite and nitrate) and gut's morphology. The data indicated that Kolaviron ameliorated chromium (VI)-induced reduction in the levels of T-SH, NP-SH, and catalase activity (p < 0.05). In addition, Kolaviron attenuated chromium (VI)-induced elevation of total peroxide, protein carbonyl, and nitric oxide (p < 0.05). Kolaviron offered a protective role in chromium VI-induced toxicity in the gut of D. melanogaster. This study provided further insights into the protective mechanisms of Kolaviron against chromium (VI)-induced toxicity in D. melanogaster by maintaining epithelial integrity of the gut and oxidative stress-antioxidant balance.

Indexed as

ChromiumDrosophila melanogasterFlavonoidsGarcinia kolaOxidative StressPlant ExtractsSeedsAnimalsAntioxidantsFemaleMaleAntioxidantsChromiumchromium hexavalent ionFlavonoidskolavironPlant ExtractsChromium (VI); KolavironDrosophila melanogasterGutMitochondrialOxidative Damage

Identifiers

PMID39425879

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.