Evidence map›Paper›PMID 39425818›Full record

ArticlePurinergic signalling2025

P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior.

Carolina Adriane Bento, Vanessa Fernandes Arnaud-Sampaio, Talita Glaser, Elena Adinolfi, Robson Coutinho-Silva, Henning Ulrich, Claudiana Lameu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Purinergic signalling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Integration of Bulk RNA Sequencing and Single-Cell Sequencing to Identify Prognostic Genes Associated With MCDRGs in Neuroblastoma.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carolina Adriane BentoMetastasis Molecular Mechanisms Laboratory and Neurosciences Laboratory, Institute of Chemistry, Biochemistry Department, University of Sao Paulo, Sao Paulo, Brazil.
Vanessa Fernandes Arnaud-SampaioMetastasis Molecular Mechanisms Laboratory and Neurosciences Laboratory, Institute of Chemistry, Biochemistry Department, University of Sao Paulo, Sao Paulo, Brazil.
Talita GlaserMetastasis Molecular Mechanisms Laboratory and Neurosciences Laboratory, Institute of Chemistry, Biochemistry Department, University of Sao Paulo, Sao Paulo, Brazil.
Elena AdinolfiSection of General Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy.
Robson Coutinho-SilvaLaboratory of Immunophysiology Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Henning UlrichMetastasis Molecular Mechanisms Laboratory and Neurosciences Laboratory, Institute of Chemistry, Biochemistry Department, University of Sao Paulo, Sao Paulo, Brazil.
Claudiana LameuMetastasis Molecular Mechanisms Laboratory and Neurosciences Laboratory, Institute of Chemistry, Biochemistry Department, University of Sao Paulo, Sao Paulo, Brazil. claulameu@usp.br.

Funding

Lacrimal Gland Repair Using Progenitor CellsR01EY026202 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI MAKARENKOVA, HELEN P. · 2016 to 2025
$5.2M
European Cooperation in Science and Technology PRESTO COST Action CA21130Fondazione AIRC per la ricerca sul cancro ETS IG22837Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro . E-26/202.774/2018Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/19128-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/07366-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/14993-5
6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs) exhibit antitumor or protumor responses related to inflammatory (or M1) and alternative (or M2) phenotypes, respectively. The P2X7 receptor plays a key role in macrophage polarization, influencing inflammation and immunosuppression. In this study, we investigated the role of the P2X7 receptor in TAMs. Using P2X7 receptor-deficient macrophages, we analyzed gene expression profiles and their implications for neuroblastoma invasion and chemoresistance. Our results showed that P2X7 receptor deficiency altered the expression of classical polarization markers, such as nitric oxide synthase 2 (Nos2) and tumor necrosis factor-α (Tnf), as well as alternative phenotype markers, including mannose receptor C-type 1 (Mrc1) and arginase 1 (Arg1). P2X7 deficiency also influenced the expression of the ectonucleotidases Entpd1 and Nt5e and other purinergic receptors, especially P2ry2, suggesting compensatory mechanisms involved in macrophage polarization. In particular, TAMs deficient in P2X7 showed a phenotype with characteristics intermideiate between resting macrophages (M0) and M1 polarization rather than the M2-type phenotype like and wild-type TAM macrophages. In addition, P2rx7

Indexed as

MacrophagesNeuroblastomaReceptors, Purinergic P2X7Tumor-Associated MacrophagesAnimalsCell Line, TumorHumansMiceP2rx7 protein, mouseReceptors, Purinergic P2X7ChemoresistanceInvasionP2Y2 receptorPurinergic signalingTumor-associated macrophages

Identifiers

PMID39425818
PMCPMC11958906

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.