Evidence map›Paper›PMID 39425758›Full record

ArticleUnited European gastroenterology journal2025

Impact of pain, fatigue and bowel incontinence on the quality of life of people living with inflammatory bowel disease: A UK cross-sectional survey.

Chris Roukas, Laura Miller, Fionn Cléirigh Büttner, Thomas Hamborg, Imogen Stagg, Alisa Hart, Vladimir Sergeevich Gordeev, James O Lindsay, Christine Norton, Borislava Mihaylova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in United European gastroenterology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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  14. Expanding Support Beyond Clinical Care in IBD Patients.United European gastroenterology journal · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Chris RoukasHealth Economics and Policy Research Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Laura MillerPragmatic Clinical Trials Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Fionn Cléirigh BüttnerPragmatic Clinical Trials Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Thomas HamborgPragmatic Clinical Trials Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Imogen StaggFaculty of Nursing, Midwifery and Palliative Care, King's College London, London, UK.
Alisa HartIBD Unit, St Mark's Hospital, London, UK.
Vladimir Sergeevich GordeevHealth Economics and Policy Research Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
James O LindsayCentre for Immunobiology, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
Christine NortonFaculty of Nursing, Midwifery and Palliative Care, King's College London, London, UK.
Borislava MihaylovaHealth Economics and Policy Research Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID 0000-0002-0951-1304

Funding

Bowel Research UK StudentshipDepartment of Health NIHR203330Department of Health RP-PG-0216-20001National Institute for Health Research Barts Biomedical Research Centre NIHR203330UK NIHR Programme Grants for Applied Research RP-PG-0216-20001
6 · The paper itself

Abstract

BACKGROUND AND

aimsPeople with inflammatory bowel disease (IBD) often experience pain, fatigue and bowel incontinence and are at an increased risk of anxiety and depression. Our aim was to assess the impact of these symptoms on health-related quality of life (QoL) in IBD.

methodsIn the IBD-BOOST survey, over 26,000 people with IBD across the UK were approached; 8486 participant-completed surveys were returned. Participants' QoL was measured using the EQ-5D-5L questionnaire and their QoL was calculated on a scale ranging from 1 (perfect health) to -0.594 (worst health). Item non-response was imputed. Stages of linear regression models assessed the associations of symptoms with QoL controlling for IBD type, socio-demographic characteristics, co-morbidities and, in further analysis, for IBD activity and IBD control.

resultsThe EQ-5D-5L questionnaire was fully completed by 8093 (95.4%) participants (mean age of 50 years [SD 15]; 49% with Crohn's disease). The mean QoL was 0.76 (SD 0.23). From the three IBD-related symptoms, pain was associated with the largest QoL decrement (-0.159), followed by fatigue (-0.140) and bowel incontinence (-0.048). Co-occurrence of pain and fatigue further reduced QoL. Clear graded associations were observed between symptom severity and QoL decrements (all trend p < 0.001). Depression and anxiety were also associated with significant QoL decrements (-0.102 and -0.110 for moderate-to-severe anxiety and moderately severe depression, respectively). Worse IBD control and higher IBD activity were associated with lower QoL.

conclusionsWe report strong associations between symptoms of pain, fatigue, bowel incontinence, anxiety, depression, and their severity and reduced QoL in IBD. These estimates could inform future IBD management interventions.

Indexed as

FatigueFecal IncontinenceInflammatory Bowel DiseasesPainQuality of LifeAdultAgedAnxietyCross-Sectional StudiesDepressionFemaleHumansMaleMiddle AgedSeverity of Illness IndexSurveys and Questionnairesbowel incontinenceCrohn's diseasefatigueinflammatory bowel diseasepainquality of lifeulcerative colitis

Identifiers

PMID39425758
PMCPMC7616848

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.