Evidence map›Paper›PMID 39425565›Full record

ArticleBritish journal of haematology2025

Comparative outcomes of various transplantation platforms, highlighting haploidentical transplants with post-transplantation cyclophosphamide for adult T-cell leukaemia/lymphoma.

Makoto Yoshimitsu, Takashi Tanaka, Nobuaki Nakano, Koji Kato, Hiroyuki Muranushi, Masahito Tokunaga, Ayumu Ito, Jun Ishikawa, Tetsuya Eto, Satoko Morishima and 14 more

Abstract readComparative Study
In one paragraph

Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Makoto YoshimitsuDepartment of Hematology and Rheumatology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.ORCID https://orcid.org/0000-0002-5935-0385
Takashi TanakaDepartment of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
Nobuaki NakanoDepartment of Hematology, Imamura General Hospital, Kagoshima, Japan.
Koji KatoDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.ORCID https://orcid.org/0000-0002-5815-4585
Hiroyuki MuranushiDepartment of Hematology, Kurashiki Central Hospital, Kurashiki, Japan.
Masahito TokunagaDepartment of Hematology, Imamura General Hospital, Kagoshima, Japan.ORCID https://orcid.org/0000-0003-1296-9006
Ayumu ItoDepartment of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
Jun IshikawaDepartment of Hematology, Osaka International Cancer Institute, Osaka, Japan.
Tetsuya EtoDepartment of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
Satoko MorishimaDivision of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), University of the Ryukyus, Okinawa, Japan.ORCID https://orcid.org/0000-0002-7391-4271
Toshiro KawakitaDepartment of Hematology, NHO Kumamoto Medical Center, Kumamoto, Japan.
Hidehiro ItonagaTransfusion and Cell Therapy Unit, Nagasaki University Hospital, Nagasaki, Japan.ORCID https://orcid.org/0000-0003-1438-3623
Naoyuki UchidaDepartment of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan.ORCID https://orcid.org/0000-0001-5952-5926
Masatsugu TanakaDepartment of Hematology, Kanagawa Cancer Center, Kanagawa, Japan.
Keiichi AkizukiDivision of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Kenji IshitsukaDepartment of Hematology and Rheumatology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Hiroyuki OhigashiDepartment of Hematology, Hokkaido University Hospital, Hokkaido, Japan.
Shuichi OtaDepartment of Hematology, Sapporo Hokuyu Hospital, Hokkaido, Japan.ORCID https://orcid.org/0000-0002-3631-244X
Toshihiko AndoDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Yoshinobu KandaDepartment of Hematology, Jichi Medical University, Tochigi, Japan.ORCID https://orcid.org/0000-0002-4866-9307
Takahiro FukudaDepartment of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
Yoshiko AtsutaJapanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan.ORCID https://orcid.org/0000-0003-4404-2870
Shigeo FujiDepartment of Hematology, Osaka International Cancer Institute, Osaka, Japan.ORCID https://orcid.org/0000-0001-5118-7950
ATL Working Group of the Japanese Society for Transplantation and Cellular Therapy

Funding

Japan Agency for Medical Research and Development (AMED) 23ck0106860h0001
6 · The paper itself

Abstract

This study retrospectively compared outcomes of various allogeneic haematopoietic cell transplantation (allo-HCT) platforms in patients with adult T-cell leukaemia/lymphoma. Platforms included human leukocyte antigen (HLA)-haploidentical-related donors using post-transplant cyclophosphamide (PTCY), HLA-matched related donors (MRD), HLA-matched unrelated donors (MUD) and cord blood transplantation (CBT). Patients who underwent their first allo-HCT between 2016 and 2021 were included. Outcomes analysed were overall survival (OS), relapse and non-relapse mortality (NRM). Seven hundred patients were included (PTCY, n = 121; MRD, n = 91; MUD, n = 160; CBT, n = 328). With a median follow-up of 794 days for survivors, 2-year OS was 48.1% (PTCY), 48.8% (MRD), 48.4% (MUD) and 34.6% (CBT); the respective 2-year cumulative incidence of relapse was 37.1%, 47.5%, 33.9% and 45.1% and that of NRM was 24.2%, 19.8%, 24.7% and 27.3%. PTCY was associated with delayed platelet engraftment relative to MRD and MUD. There was no increase in the incidence of severe acute or chronic graft-versus-host disease. In the PTCY group, poor performance status was a significant predictor of inferior OS, and infused CD34+ cell numbers of less than 5 × 10

Indexed as

CyclophosphamideHematopoietic Stem Cell TransplantationLeukemia-Lymphoma, Adult T-CellTransplantation, HaploidenticalAdolescentAdultAgedFemaleGraft vs Host DiseaseHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeYoung AdultCyclophosphamideadult T‐cell leukaemia/lymphomagraft‐versus‐host diseasehaploidentical haematopoietic stem cell transplantationpost‐transplant cyclophosphamideprophylaxis

Identifiers

PMID39425565
PMCPMC11739753

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.