Evidence map›Paper›PMID 39425535›Full record

ArticleEpigenetics2024

Parental arsenic exposure and tissue-specific DNA methylation in Bangladeshi infants with spina bifida.

Gwen Tindula, Sudipta Kumer Mukherjee, Sheikh Muhammad Ekramullah, D M Arman, Joynul Islam, Subrata Kumar Biswas, Benjamin C Warf, David C Christiani, Bernardo Lemos, Liming Liang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gwen TindulaDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.
Sudipta Kumer MukherjeeDepartment of Paediatric Neurosurgery, National Institute of Neurosciences and Hospital (NINS&H), Dhaka, Bangladesh.
Sheikh Muhammad EkramullahDepartment of Paediatric Neurosurgery, National Institute of Neurosciences and Hospital (NINS&H), Dhaka, Bangladesh.
D M ArmanDepartment of Paediatric Neurosurgery, National Institute of Neurosciences and Hospital (NINS&H), Dhaka, Bangladesh.
Joynul IslamDepartment of Clinical Neurosurgery, National Institute of Neurosciences and Hospital (NINS&H), Dhaka, Bangladesh.
Subrata Kumar BiswasDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA.
Benjamin C WarfDepartment of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.
David C ChristianiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Bernardo LemosDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Liming LiangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Andres CardenasDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.
Maitreyi MazumdarDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Funding

VARIATION IN BIOACCUMULATION AND BIOMAGNIFICATION OF METALS IN NORTHERN US LAKESP42ES007373 · NIEHS · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 1995 to 2019
$52.0M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Translational Post-doctoral Training in NeurodevelopmentT32MH112510 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI DAVID C GLAHN, CHARLES Alexander NELSON · 2017 to 2026
$2.6M
Interdisciplinary approaches for understanding how arsenic and micronutrients affect the epigenome to influence spina bifida riskR01ES034713 · NIEHS · BOSTON CHILDREN'S HOSPITAL · PI MAZUMDAR, MAITREYI · 2023 to 2025
$2.3M
Does arsenic increase risk of neural tube defects in a highly-exposed population?R01ES026317 · NIEHS · BOSTON CHILDREN'S HOSPITAL · PI MAZUMDAR, MAITREYI · 2016 to 2020
$2.2M
Examining tissue-specific DNA methylation after prenatal exposure to arsenic among infants with spina bifidaR21ES030784 · NIEHS · BOSTON CHILDREN'S HOSPITAL · PI MAZUMDAR, MAITREYI · 2020 to 2021
$497k
NICHD NIH HHS P50 HD105351NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P42 ES007373NIEHS NIH HHS R01 ES026317NIEHS NIH HHS R01 ES034713NIEHS NIH HHS R21 ES030784NIMH NIH HHS T32 MH112510
6 · The paper itself

Abstract

An emerging hypothesis linking arsenic toxicity involves altered epigenetic mechanisms, such as DNA methylation. In this study, we examined the relationship between parents' arsenic exposure and DNA methylation in tissues obtained from 28 infants with spina bifida from Bangladesh. We analyzed arsenic in parents' toenails using inductively coupled plasma mass spectrometry (ICP-MS). DNA methylation was measured in infants' dural tissue, buccal swabs, and whole blood using the Illumina Infinium MethylationEPIC BeadChip. We performed epigenome-wide association analyses (EWAS) and tested differentially methylated regions (DMRs). In EWAS, DNA methylation at cg24039697 in dural tissue was positively associated (β = 0.59,

Indexed as

ArsenicDNA MethylationSpinal DysraphismAdultBangladeshCpG IslandsEpigenesis, GeneticFemaleHumansInfantInfant, NewbornMaleNailsPaternal ExposureArsenicArsenicBangladeshenvironmental epidemiologyepigeneticsfolateneural tube defects

Identifiers

PMID39425535
PMCPMC11492674

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.