Evidence map›Paper›PMID 39425033›Full record

ArticleBMC molecular and cell biology2024

Induction of chronic asthma up regulated the transcription of senile factors in male rats.

Majid Hassanzadeh-Khanmiri, Rana Keyhanmanesh, Reza Mosaddeghi-Heris, Aref Delkhosh, Jafar Rezaie, Sajjad Taghizadeh, Mehdi Rezai Seghin Sara, Mahdi Ahmadi

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Article in BMC molecular and cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Majid Hassanzadeh-KhanmiriTuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Rana KeyhanmaneshDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Reza Mosaddeghi-HerisNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Aref DelkhoshDepartment of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Jafar RezaieSolid Tumor Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.
Sajjad TaghizadehStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Mehdi Rezai Seghin SaraStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Mahdi AhmadiTuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. mahdi59866@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe main characteristic of asthma is chronic inflammation. We examined cellular senescence by histology and molecular assay in the lungs of a rat model of asthma. This model comprises sensitization by several intraperitoneal injections of ovalbumin with aluminium hydroxide, followed by aerosol challenges every other day.

resultsData showed that asthma induction caused histological changes including, hyperemia, interstitial pneumonia, fibrinogen clots, and accumulation of inflammatory cells in the pleura. There is an elevation of IL-1β and NF-kB proteins in the asthmatic group (P < 0.001) compared to the control group. The expression of ß-galactosidase increased (P < 0.01), while the expression of Klotho and Sox2 genes was decreased in the lung tissue of the asthmatic group (P < 0.01).

conclusionTaken together, these findings suggest that asthmatic conditions accelerated the cellular senescence in the lung tissue.

Indexed as

AsthmaCellular SenescenceGlucuronidaseLungAnimalsbeta-GalactosidaseChronic DiseaseDisease Models, AnimalInterleukin-1betaMaleNF-kappa BOvalbuminRatsSOXB1 Transcription FactorsTranscription, GeneticUp-Regulationbeta-GalactosidaseGlucuronidaseInterleukin-1betaNF-kappa BOvalbuminSOXB1 Transcription FactorsAsthmaCellular senescenceInflammationß-galactosidase

Identifiers

PMID39425033
PMCPMC11492212

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.