Evidence map›Paper›PMID 39425006›Full record

ArticleBMC microbiology2024

Comprehensive genomic analysis of Brevibacillus brevis BF19 reveals its biocontrol potential against bitter gourd wilt.

Luyang Song, Yue Shen, Huihao Zhang, Han Zhang, Yuanyuan Zhang, Mengjiao Wang, Mingyue Zhang, Fei Wang, Lin Zhou, Caiyi Wen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Comparative Genomic Analysis ofMicroorganisms · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Luyang SongCollege of Plant Protection, Henan Agricultural University, Zhengzhou, 450046, China.
Yue ShenFood Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
Huihao ZhangCollege of Plant Protection, Henan Agricultural University, Zhengzhou, 450046, China.
Han ZhangCollege of Plant Protection, Henan Agricultural University, Zhengzhou, 450046, China.
Yuanyuan ZhangCollege of Plant Protection, Henan Agricultural University, Zhengzhou, 450046, China.
Mengjiao WangCollege of Plant Protection, Henan Agricultural University, Zhengzhou, 450046, China.
Mingyue ZhangCollege of Plant Protection, Henan Agricultural University, Zhengzhou, 450046, China.
Fei WangInstitute of Plant Protection, Henan Academy of Agricultural Sciences, Zhengzhou, 450002, China.
Lin ZhouCollege of Plant Protection, Henan Agricultural University, Zhengzhou, 450046, China.
Caiyi WenCollege of Plant Protection, Henan Agricultural University, Zhengzhou, 450046, China.
Ying ZhaoCollege of Plant Protection, Henan Agricultural University, Zhengzhou, 450046, China. zhaoying@henau.edu.cn.

Funding

Henan Provincial Science and Technology Major Project 221100110100Science and Technology Planning Project of Henan Province of China 242102110190Science and Technology Planning Project of Henan Province of China 242102111102
6 · The paper itself

Abstract

Bitter gourd wilt, a severe vascular disease triggered by the soilborne pathogen Fusarium oxysporum f. sp. momordicae (FOM), markedly constrains bitter gourd yield. In this study, a novel strain BF19 of Brevibacillus brevis was isolated and identified, exhibiting strong antimicrobial activity against FOM through in vivo and in vitro experiments. To comprehensively assess the biocontrol potential of strain BF19, we conducted phenotypic, phylogenetic, and comparative genomics analyses. Phenotypic analysis revealed that BF19 exhibited 53.33% biocontrol efficacy and significantly increased the average plant height, root fresh weight, and dry weight. Whole-genome sequencing and comparative genomic analysis revealed numerous potential genes associated with biocontrol mechanisms in BF19. Importantly, the integration of metabolic cluster prediction with liquid chromatography‒tandem mass spectrometry (LC‒MS/MS) revealed the presence of a macrobrevin antibiotic, a product of polyketide synthases (PKSs), predominantly in BF19 fermentation products. The effectiveness of the Br. brevis strain BF19 and its crude extract against bitter gourd wilt has also been confirmed. This study provides a genetic framework for future investigations on PKSs and establishes a scientific basis for optimizing field applications of microbial biopesticides derived from Br. brevis BF19.

Indexed as

BrevibacillusFusariumPhylogenyPlant DiseasesBiological Control AgentsGenome, BacterialGenomicsTandem Mass SpectrometryWhole Genome SequencingBiological Control AgentsAntimicrobial activityBiocontrolBrevibacillus brevisFusarium oxysporumWhole-genome sequencing

Identifiers

PMID39425006
PMCPMC11488265

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.