Evidence map›Paper›PMID 39424894›Full record

ArticleScientific reports2024

Similar humoral responses but distinct CD4

Huy Quang Quach, Iana H Haralambieva, Krista M Goergen, Diane E Grill, Jun Chen, Inna G Ovsyannikova, Gregory A Poland, Richard B Kennedy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huy Quang QuachDepartment of Internal Medicine, Vaccine Research Group, Mayo Clinic, Rochester, MN, 55905, USA.
Iana H HaralambievaDepartment of Internal Medicine, Vaccine Research Group, Mayo Clinic, Rochester, MN, 55905, USA.
Krista M GoergenDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, 55905, USA.
Diane E GrillDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, 55905, USA.
Jun ChenDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, 55905, USA.
Inna G OvsyannikovaDepartment of Internal Medicine, Vaccine Research Group, Mayo Clinic, Rochester, MN, 55905, USA.
Gregory A PolandDepartment of Internal Medicine, Vaccine Research Group, Mayo Clinic, Rochester, MN, 55905, USA.
Richard B KennedyDepartment of Internal Medicine, Vaccine Research Group, Mayo Clinic, Rochester, MN, 55905, USA. kennedy.rick@mayo.edu.

Funding

COVID Supplement - COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES,75N93019C00052 · NIAID · UNIVERSITY OF GEORGIA · PI ROSS, TED · 2019 to 2025
$74.6M
Bioinformatics Approach to Influenza A/H1N1 Vaccine Immune ProfilingU01AI089859 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 2010 to 2015
$33.8M
Transcriptomic Signatures of Influenza Vaccine ResponsesR01AI132348 · NIAID · MAYO CLINIC ROCHESTER · PI KENNEDY, RICHARD B, POLAND, GREGORY A. · 2018 to 2022
$3.9M
National Institute of Allergy and Infectious Diseases R01AI132348NIAID NIH HHS 75N93019C00052NIAID NIH HHS R01 AI132348NIAID NIH HHS U01 AI089859
6 · The paper itself

Abstract

Older age (≥ 65 years) is associated with impaired responses to influenza vaccination, leading to the preferential recommendation of MF59-adjuvanted (MF59Flu) or high-dose (HDFlu) influenza vaccines for this age group in the United States. Herein, we characterized transcriptomic profiles of CD4

Indexed as

Adjuvants, ImmunologicCD4-Positive T-LymphocytesInfluenza, HumanInfluenza VaccinesPolysorbatesSqualeneTranscriptomeAgedAged, 80 and overAntibodies, ViralFemaleGene Expression ProfilingHumansImmunity, HumoralInfluenza A Virus, H3N2 SubtypeMaleAdjuvants, ImmunologicAntibodies, ViralInfluenza VaccinesMF59 oil emulsionPolysorbatesSqualeneCD4+ T cellsGene expression profilingHigh-dose influenza vaccineMF59-adjuvanted influenza vaccineOlder adults

Identifiers

PMID39424894
PMCPMC11489691

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.