ArticleNature communications2024
Changes in cortical manifold structure following stroke and its relation to behavioral recovery in the male macaque.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Enhanced motor recovery in stroke patients through dual-modal intervention: motor imagery and task-oriented robot training.Journal of neuroengineering and rehabilitation · 2025Trial
- Considering biological limitations of lesion network mapping.Nature neuroscience · 2026Article
- Hirudin as a Therapeutic and Brain-Delivery Platform: From Stroke to Central Nervous System Disorders.International journal of molecular sciences · 2026Review
- Longitudinal Degeneration of Microstructural and Structural Connectivity Patterns Following Stroke.Stroke · 2026Article
- Disrupted integration-segregation balance in the intact hemisphere in chronic spatial neglect.Brain structure & function · 2026Article
- Review
- The retrieval of previously learned motor memories is facilitated by the reinstatement of default mode network manifold structures.PLoS biology · 2026Article
- Quantitative assessment of dynamic movement reveals deficits due to hemiparetic stroke.Journal of neuroengineering and rehabilitation · 2025Article
- From gradients to cognition: linking cortical manifolds to brain flexibility and disorder.Frontiers in cognition · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Stroke, a major cause of disability, disrupts brain function and motor skills. Previous research has mainly focused on reorganization of the motor system post-stroke, but the effects on other brain areas and their influence on recovery is poorly understood. Here, we use functional neuroimaging in a nonhuman primate model (23 male Cynomolgus Macaques), we explore how ischemic stroke affects whole-brain cortical architecture and its relation to spontaneous behavioral recovery. By projecting patterns of cortical functional connectivity onto a low-dimensional manifold space, we find that several regions in both sensorimotor cortex and higher-order transmodal cortex exhibit significant shifts in their manifold embedding from pre- to post-stroke. Furthermore, we observe that changes in default mode and limbic network regions, and not preserved sensorimotor cortical regions, are associated with animal behavioral recovery post-stroke. These results establish the whole-brain functional changes associated with stroke, and suggest an important role for higher-order transmodal cortex in post-stroke outcomes.
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Registered trials
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