ArticleScientific reports2024
Evaluating brain volume segmentation accuracy and reliability of FreeSurfer and Neurophet AQUA at variations in MRI magnetic field strengths.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- MRI measurement of the delayed secondary ischaemic injury following endovascular thrombectomy: results from the REPERFUSE-NA1 study.European stroke journal · 2026Trial
- Validation of Compressed Sensing Accelerated Magnetization Prepared Rapid Acquisition Gradient Echo for Fast and Reliable Brain Volume Measurement.Tomography (Ann Arbor, Mich.) · 2026Article
- Comparative Analysis of Four Commercially Available Artificial Intelligence Software for Brain Volumetry.Diagnostics (Basel, Switzerland) · 2026Article
- A computational model to describe multi-regional brain architecture during neurodegeneration in Alzheimer's disease.Scientific reports · 2026Article
- The potential of low-field MRI for global dementia care.Nature reviews. Neurology · 2026Review
- Cerebellar subregional structural changes across the Alzheimer's disease continuum: a longitudinal analysis of cognitive and behavioural correlates.Brain communications · 2026Article
- The efficacy of multisite MRI scanners for total brain volume measurements: a cross-sectional study in Saudi Arabia.Frontiers in radiology · 2026Article
- Estimation of reference curves for brain atrophy and analysis of robustness to machine effects.Scientific reports · 2025Article
- Hypothalamus and intracranial volume segmentation at the group level by use of a Gradio-CNN framework.International journal of computer assisted radiology and surgery · 2025Article
- Multi-center evaluation of Neurophet AQUA for brain MRI segmentation: T1 compared with FreeSurfer and T2-FLAIR compared with ground truth.Frontiers in neurology · 2025Article
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9 authors.
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Abstract
We aimed to compare the accuracy and reliability of two segmentation tools for magnetic resonance (MR) volumetry (FreeSurfer and Neurophet AQUA) at two magnetic field strengths (1.5T and 3T). We included 101 patients for the 1.5T-3T dataset and 112 for the 3T-3T dataset from three hospitals and five open-source datasets. The mean volume difference and average volume difference percentage with the change in magnetic field strength were compared between the methods. The hippocampus volume was larger with FreeSurfer than the Neurophet AQUA. In most brain regions, the Neurophet AQUA yielded a smaller average volume difference percentage (all < 10%) than FreeSurfer (all > 10%). The Neurophet AQUA exhibited more stable connectivity and regularity of the segmented components. Regarding volume, the Neurophet AQUA had effect sizes and ICCs comparable to those of FreeSurfer across the magnetic field strengths. With FreeSurfer, the original volume difference was small, whereas the average volume difference percentage was small with the Neurophet AQUA. Image segmentation took 1 h with FreeSurfer and 5 min with the Neurophet AQUA. When choosing an automatic segmentation method, the differences in image processing time and volume variability due to changes in the magnetic field strength of these methods should be considered.
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