Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Sunita MaharjanDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0002-7099-1802
Howard GamperDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0001-9007-8546
Yuka YamakiDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0003-2457-7296
Thomas ChristianDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Robert Y HenleyDepartment of Physics, Northeastern University, Boston, MA, USA.
Nan-Sheng LiDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Takeo SuzukiFaculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Tsutomu SuzukiDepartment of Chemistry and Biotechnology, University of Tokyo, Tokyo, Japan.ORCID 0000-0002-9731-1731
Joseph A PiccirilliDepartment of Chemistry, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-0541-6270
Meni WanunuDepartment of Physics, Northeastern University, Boston, MA, USA.ORCID 0000-0002-9837-0004
Erin SeifertDepartment of Pathology, Thomas Jefferson University, Philadelphia, PA, USA.
Douglas C WallaceCenter for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Department of Pediatrics, Division of Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ya-Ming HouDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA. ya-ming.hou@jefferson.edu.ORCID 0000-0001-6546-2597
Funding
tRNA in codon usageR35GM134931 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI HOU, YA-MING · 2020 to 2025
$5.4M
Role of Adaptive Immunity in Etiology of Alzheimer’s Disease andAlzheimer’s Disease-Related DementiasR01AG078814 · NIA · CHILDREN'S HOSP OF PHILADELPHIA · PI Douglas C Wallace · 2022 to 2026
$4.2M
Anti-tumor immunity and intestinal microbiota are modulated by mitochondrial DNAR01CA259635 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI Douglas C Wallace · 2022 to 2026
$3.2M
Structure and Function of Non-Coding RNAR35GM149336 · NIGMS · UNIVERSITY OF CHICAGO · PI Joseph Anthony Piccirilli · 2023 to 2026
$2.8M
Pathogensis of myopathies caused by novel mitochondrial phosphate carrier mutationsR01GM123771 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI SEIFERT, ERIN · 2017 to 2020
Human mitochondrial tRNAs (mt-tRNAs), critical for mitochondrial biogenesis, are frequently associated with pathogenic mutations. These mt-tRNAs have unusual sequence motifs and require post-transcriptional modifications to stabilize their fragile structures. However, whether a modification that stabilizes a wild-type (WT) mt-tRNA would also stabilize its pathogenic variants is unknown. Here we show that the N
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Post-transcriptional methylation of mitochondrial-tRNA differentially contributes to mitochondrial pathology. · full record | OpenQuestion