ArticleNature communications2024
Mechanisms of epigenomic and functional convergence between glucocorticoid- and IL4-driven macrophage programming.
Abstract read
In one paragraph
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- A transcriptional cofactor GRIP1 drives PPARγ DNA binding and p300-dependent enhancer activity during homeostatic macrophage polarization.Science advances · 2026Article
- Multi-level transcriptional control of specific macrophage responses.The EMBO journal · 2026Review
- Macrophage programming in systemic sclerosis: Niches, networks, and translational horizons.Seminars in immunopathology · 2026Review
- CD163Biomarker research · 2026Article
- Patient-derived tissue slice cultures from endoscopic biopsies as a translational ex vivo model for inflammatory bowel diseases.Clinical and experimental medicine · 2026Article
- The Emerging Role of Ly6G⁺Nur77⁺ Lung Macrophages in Type-2 Allergic Inflammation: A Comprehensive Review on Asthma Pathogenesis.Current allergy and asthma reports · 2026Review
- Beyond M1/M2: The Pivotal Role of Macrophage Metabolic Reprogramming in Chronic Bone Disease and Targeted Intervention.International journal of molecular sciences · 2026Review
- Chitinase-like proteins de-N-glycosylating CD36 modify cholesterol metabolism in atherosclerotic macrophages.Nature communications · 2026Article
- The PI3K-AKT pathway mediates the imbalance of bone marrow macrophage polarization in patients with immune thrombocytopenia.Journal of translational medicine · 2026Article
- <p>Regulatory networks of HIFs in tumor‑infiltrating immune cells: From molecular mechanisms to therapeutic implications (Review)</p>.International journal of oncology · 2026Review
- Timing of Glucocorticoid Treatment Dictates Glucocorticoid Receptor Actions Modulating the NLRP3-Inflammasome Activation in Macrophages.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Selective Glucocorticoid Receptor Modulators of Immune Checkpoint Function.bioRxiv : the preprint server for biology · 2026Article
- The gene regulatory networks shaping macrophage plasticity and altered function in fibrosis.Frontiers in immunology · 2026Review
- Microglia-specific interleukin-4 delivery by engineered extracellular vesicles restores inner blood-retinal barrier in diabetic retinopathy via GAS6-MERTK pathway.Journal of nanobiotechnology · 2025Article
- Macrophages at the Crossroads of Chronic Stress and Cancer.International journal of molecular sciences · 2025Review
- Immunoporosis: The hidden link between aging immune cells and bone fragility.Journal of orthopaedic translation · 2025Review
Corrections and comments
- Update of
Authors and funding
9 authors.
Dinesh K DeochandHospital for Special Surgery Research Institute, David Z. Rosensweig Genomics Center, New York, NY, USA.ORCID 0000-0002-7395-9250
Marija DacicHospital for Special Surgery Research Institute, David Z. Rosensweig Genomics Center, New York, NY, USA.
Michael J BaleDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-6899-1459
Andrew W DamanDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-8144-0574
Vidyanath ChaudharyHospital for Special Surgery Research Institute, David Z. Rosensweig Genomics Center, New York, NY, USA.
Steven Z JosefowiczDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-7453-779X
David OliverHospital for Special Surgery Research Institute, David Z. Rosensweig Genomics Center, New York, NY, USA.
Yurii ChinenovHospital for Special Surgery Research Institute, David Z. Rosensweig Genomics Center, New York, NY, USA.
Inez RogatskyHospital for Special Surgery Research Institute, David Z. Rosensweig Genomics Center, New York, NY, USA. rogatskyi@hss.edu.ORCID 0000-0003-3514-5077
Funding
Glucocorticoid-regulated transcription networks in macrophage biologyR01DK099087 · NIDDK · HOSPITAL FOR SPECIAL SURGERY · PI INEZ ROGATSKY · 2014 to 2026
$6.0MHistone Variant H3.3 as a Transcription Rheostat in the Immune SystemR01AI148416 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Steven Zvi Josefowicz · 2020 to 2026
$4.6MPost-Initiation control of transcription in inflammatory macrophagesR01AI148129 · NIAID · HOSPITAL FOR SPECIAL SURGERY · PI ROGATSKY, INEZ · 2020 to 2024
$3.0MDescribing the Epigenetic Mechanisms in Control of Hematopoietic Development and Rapid Inflammatory ResponsesF31HL152706 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DAMAN, ANDREW · 2021 to 2023
$140kNHLBI NIH HHS F31 HL152706NIAID NIH HHS R01 AI148129NIAID NIH HHS R01 AI148416NIDDK NIH HHS R01 DK099087U.S. Department of Health & Human Services | National Institutes of Health (NIH) F31 HL152706-01A1U.S. Department of Health & Human Services | National Institutes of Health (NIH) NIH R01AI148129U.S. Department of Health & Human Services | National Institutes of Health (NIH) NIH R01AI148416U.S. Department of Health & Human Services | National Institutes of Health (NIH) NIH R01DK099087
Abstract
Macrophages adopt distinct phenotypes in response to environmental cues, with type-2 cytokine interleukin-4 promoting a tissue-repair homeostatic state (M2
Indexed as
GlucocorticoidsInterleukin-4Kruppel-Like Factor 4Kruppel-Like Transcription FactorsMacrophagesReceptors, GlucocorticoidAdaptor Proteins, Signal TransducingAnimalsColitisEpigenomicsHomeostasisMaleMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsAdaptor Proteins, Signal TransducingGlucocorticoidsGrip1 protein, mouseIl4 protein, mouseInterleukin-4Klf4 protein, mouseKruppel-Like Factor 4Kruppel-Like Transcription FactorsNerve Tissue ProteinsReceptors, Glucocorticoid
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.