Evidence map›Paper›PMID 39424688›Full record

ReviewFunctional & integrative genomics2024

The Integrator complex: an emerging complex structure involved in the regulation of gene expression by targeting RNA polymerase II.

Tingyue Li, Fulei Zeng, Yang Li, Hu Li, Jiayuan Wu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Functional & integrative genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tingyue LiSchool of Stomatology, Affiliated Stomatological Hospital, Zunyi Medical University, Zunyi, Guizhou, 563000, China.
Fulei ZengSchool of Stomatology, Affiliated Stomatological Hospital, Zunyi Medical University, Zunyi, Guizhou, 563000, China.
Yang LiSchool of Stomatology, Affiliated Stomatological Hospital, Zunyi Medical University, Zunyi, Guizhou, 563000, China.
Hu LiSchool of Stomatology, Affiliated Stomatological Hospital, Zunyi Medical University, Zunyi, Guizhou, 563000, China.
Jiayuan WuSchool of Stomatology, Affiliated Stomatological Hospital, Zunyi Medical University, Zunyi, Guizhou, 563000, China. wujiayuan@zmu.edu.cn.

Funding

Jiayuan Wu ZKH [2023]-81
6 · The paper itself

Abstract

The Integrator complex is a multisubunit complex that participates in the processing of small nuclear RNA molecules in eukaryotic cells by cleaving the 3' end. In protein-coding genes, Integrator is a key regulator of promoter-proximal pausing, release, and recruitment of RNA polymerase II. Research on Integrator has revealed its critical role in the regulation of gene expression and RNA processing. Dysregulation of the Integrator complex has been implicated in a variety of human diseases including cancer and developmental disorders. Therefore, understanding the structure and function of the Integrator complex is critical to uncovering the mechanisms of gene expression and developing potential therapeutic strategies for related diseases.

Indexed as

RNA Polymerase IIAnimalsGene Expression RegulationHumansPromoter Regions, GeneticRNA, Small NuclearTranscription, GeneticRNA Polymerase IIRNA, Small NuclearCancerDevelopmental disordersIntegratorRNA polymerase IITranscriptional regulation

Identifiers

PMID39424688

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.