Evidence map›Paper›PMID 39424648›Full record

SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Combinations of physical and cognitive training for subcortical neurodegenerative diseases with physical, cognitive and behavioral symptoms: a systematic review.

Coline Chartier, Julien Godard, Sylvain Durand, Anne Humeau-Heurtier, Emmanuelle Menetrier, Philippe Allain, Jérémy Besnard

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Letter to the editor to "The effect of non-pharmacological interventions on cognitive function in cancer: an overview of systematic reviews".Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  3. Review
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Coline Chartier *Univ Angers, Nantes Université, CHU Angers, LPPL, SFR CONFLUENCES, UR4638, F-49000, Angers, France.ORCID http://orcid.org/0009-0007-3563-5320
Julien Godard *Univ Angers, LARIS, SFR MATHSTIC, F-49000, Angers, France. julien.godard@univ-angers.fr.ORCID http://orcid.org/0009-0002-1328-5204
Sylvain DurandLe Mans Université, MIP, UR4334, F-72000, Le Mans, France.ORCID http://orcid.org/0000-0003-1268-1694
Anne Humeau-HeurtierUniv Angers, LARIS, SFR MATHSTIC, F-49000, Angers, France.ORCID http://orcid.org/0000-0002-6289-0040
Emmanuelle MenetrierUniv Angers, Nantes Université, LPPL, SFR CONFLUENCES, UR4638, F-49000, Angers, France.ORCID http://orcid.org/0000-0001-5189-5367
Philippe AllainUniv Angers, Nantes Université, CHU Angers, LPPL, SFR CONFLUENCES, UR4638, F-49000, Angers, France.ORCID http://orcid.org/0000-0003-0668-0986
Jérémy BesnardUniv Angers, Nantes Université, LPPL, SFR CONFLUENCES, UR4638, F-49000, Angers, France.ORCID http://orcid.org/0000-0001-7127-7558

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe onset of the symptoms of subcortical NDs is due to a unique part of the brain which strengthens the idea of reciprocal influence of physical activity and cognitive training in improving clinical symptoms. Consequently, protocols combining the two stimulations are becoming increasingly popular in NDs. Our threefold aim was to (A) describe the different combinations of physical and cognitive training used to alleviate the motor and cognitive symptoms of patients with subcortical neurodegenerative disorders, (B) compare the effects of these different combinations (sequential, dual tasking, synergical) on symptoms, and (C) recommend approaches for further studies.

methodsWe conducted literature searches of PubMed, BASE and ACM, to carry out a systematic review of randomized controlled trials and controlled trials of combined physical and cognitive training among patients with Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, Lewy body dementia, spinocerebellar ataxia, Friedreich's ataxia, and progressive supranuclear palsy. Physical, neuropsychological, behavioral outcomes were considered. The Cochrane risk-of-bias tool was used to verify the critical appraisal.

resultsTwenty-one studies focused on Parkinson's disease with 940 participants were included. Despites promising benefits on cognitive and physical function, our results revealed discrepant findings for research on combined training. DISCUSSION: Inconsistencies were linked to the choice of tests, the functions that were targeted, disease progression, and trainings. There was a dearth of follow-up data.

conclusionsDifferences between combined training are unclear, particularly regarding the role of cognitive load. Future studies should focus on comparing the feasibility, tolerability, and effectiveness of different combinations of motor-cognitive training.

Indexed as

Neurodegenerative DiseasesBehavioral SymptomsCognitive Behavioral TherapyCognitive DysfunctionCognitive TrainingExercise TherapyHumansCognitive stimulationCombined trainingDual taskNeurodegenerative disorderPhysical exercise

Identifiers

PMID39424648
PMCPMC11554706

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.