Evidence map›Paper›PMID 39424420›Full record

ArticleJournal of the American Heart Association2024

Association of Coronary Microvascular Rarefaction and Myocardial Fibrosis With Coronary Artery Disease.

Duncan J Campbell, Victoria C M Francis, Gregory R Young, Noel W F Woodford

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Can we better prevent cardiovascular disease? 'Stayin' healthy to stay alive'.International journal of cardiology. Cardiovascular risk and prevention · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Duncan J CampbellSt. Vincent's Institute of Medical Research Fitzroy Victoria Australia.ORCID 0000-0002-6896-7571
Victoria C M FrancisDepartment of Forensic Medicine, School of Public Health and Preventive Medicine Monash University Southbank Victoria Australia.ORCID 0000-0002-4681-8460
Gregory R YoungDepartment of Forensic Medicine, School of Public Health and Preventive Medicine Monash University Southbank Victoria Australia.ORCID 0009-0000-6013-528X
Noel W F WoodfordDepartment of Forensic Medicine, School of Public Health and Preventive Medicine Monash University Southbank Victoria Australia.ORCID 0009-0003-8867-5925

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate, in a cohort study, whether coronary microvasculature and myocardial structure differ between people with and without coronary artery disease (CAD). METHODS AND

resultsWe performed histological analysis of left ventricle free wall obtained at autopsy from 25 men and 23 women with ≥1 coronary artery with ≥75% area stenosis, and 25 men and 25 women without (no or minimal) CAD, matched for sex and age, who died suddenly from noncardiac causes. Decedents with myocardial infarction or other cardiac abnormality were excluded. Decedents with and without CAD had similar height and weight. Heart weight of decedents with CAD was higher than that of decedents without CAD (mean, 391 versus 364 g; mean difference, 27 g [95% CI, 0.3-54.0],

conclusionsCAD was associated with coronary microvascular rarefaction and increased myocardial fibrosis. The association of CAD with coronary microvascular rarefaction and increased myocardial fibrosis may contribute to the increased risks of death, myocardial infarction and heart failure that accompany CAD, and may attenuate the impact of percutaneous coronary intervention on cardiovascular risk in people with stable angina.

Indexed as

Coronary Artery DiseaseCoronary VesselsFibrosisMicrovascular RarefactionMyocardiumAgedAged, 80 and overAutopsyCase-Control StudiesCoronary CirculationFemaleHumansMaleMiddle Agedcoronary artery diseasecoronary microvasculaturemyocardial fibrosis

Identifiers

PMID39424420
PMCPMC11935736

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.