Evidence map›Paper›PMID 39424380›Full record

ArticleBMJ open2024

NEARER SCAN (LENO BESIK) evaluation of a task-sharing echocardiographic active case finding programme for rheumatic heart disease in Australia and Timor-Leste: protocol for a hybrid type II effectiveness-implementation study.

Benjamin Jones, James Marangou, Jennifer Yan, Anna Ralph, Alice Mitchell, Alex Kaethner, Bo Remenyi, Vicki Wade, Judith M Katzenellenbogen, Anferida Fernandes Monteiro and 31 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06002243 (Non-Expert Acquisition and Remote Expert Review of Screening Echocardiography Images From Child Health and AnteNatal Clinics), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06002243 naunknown statusnot on this map

Non-Expert Acquisition and Remote Expert Review of Screening Echocardiography Images From Child Health and AnteNatal Clinics (NEARER SCAN)

TypeinterventionalSponsorMenzies School of Health ResearchRan2024 to 2025Enrolled1,500ConditionsRheumatic Heart DiseaseArmsSPLASH echocardiography screening
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Acute rheumatic fever and rheumatic heart disease.Nature reviews. Disease primers · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Benjamin JonesHealth Systems Collaborative, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-8035-3150
James MarangouMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Jennifer YanMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Anna RalphMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.ORCID 0000-0002-2253-5749
Alice MitchellMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Alex KaethnerMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Bo RemenyiMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Vicki WadeMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Judith M KatzenellenbogenSchool of Population and Global Health, University of Western Australia, Crawley, Western Australia, Australia.ORCID 0000-0001-5287-5819
Anferida Fernandes MonteiroMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Jeffrey W CannonWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, Western Australia, Australia.
Natasha J HowardSouth Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID 0000-0002-8099-3107
Marisa GillesWestern Australia Country Health Service, Perth, Western Australia, Australia.
Emma HaynesUniversity of Western Australia, Perth, Western Australia, Australia.
Herculano SeixasHospital Nacional Guido Valadares, Dili, Timor-Leste.
Joaquina MauraysMaluk Timor, Dili, Timor-Leste.
Jade NeaveMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Chantelle PearsWestern Australia Country Health Service, Perth, Western Australia, Australia.
Daniel EngelmanMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Karla CanutoFlinders University, Adelaide, South Australia, Australia.
Andrew SteerDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.
Holger UngerMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Meghan BaileyMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Maria TanesiMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Salvador AmaralMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Helder NetoTimor-Leste Ministerio da Saude, Dili, Timor-Leste.
Maida StewartMiwatj Health Service, Darwin, Northern Territory, Australia.
Paul BurgessNorthern Territory Government of Australia, Darwin, Northern Territory, Australia.
Alex BrownIndigenous Genomics, Australian National University, Canberra, Australian Capital Territory, Australia.
Bart J CurrieDepartment of Infectious Diseases, Royal Darwin Hospital, Casuarina, Northern Territory, Australia.
Graham HillisSchool of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0003-2417-4673
Peter MorrisMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
David SimonKatherine Hospital, Katherine, Northern Territory, Australia.
Gavin WheatonDepartment of Cardiology, Women's and Children's Hospital, Adelaide, South Australia, Australia.
Jacqui WilliamsonMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Jessica de DasselMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Simon Slota-KanWestern Australia Country Health Service, Perth, Western Australia, Australia.
Jonathan CarapetisTelethon Kids Institute, Perth, Western Australia, Australia.
Mike EnglishHealth Systems Collaborative, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-7427-0826
Shobhana NagrajHealth Systems Collaborative, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Joshua R FrancisMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia josh.francis@menzies.edu.au.ORCID 0000-0001-9302-4543

Funding

Wellcome Trust
6 · The paper itself

Abstract

introductionRheumatic heart disease (RHD) is underdiagnosed globally resulting in missed treatment opportunities and adverse clinical outcomes. We describe the protocol for a study which aims to co-design, implement and conduct an evaluation of a task-sharing approach to echocardiographic active case finding for early detection and management of RHD in high-risk settings in Australia and Timor-Leste. METHODS AND ANALYSIS: Echocardiograms will be obtained by trained local staff using hand-held echocardiographic devices employing the 'Single Parasternal Long Axis view with a Sweep of the Heart' (SPLASH) technique and interpreted by experts remote from the site of acquisition. Approximately 1500 children and pregnant women will be screened across high-risk communities in Australia and Timor-Leste over an 18-month period. The study will use a type II effectiveness-implementation hybrid design. A tailored package of implementation strategies will be co-designed with communities and health services and mapped onto a Theory of Change framework. The clinical effectiveness will be assessed as the change in the proportion of the target population that are prescribed secondary prophylaxis for RHD by the end of the study compared with baseline. The implementation will be assessed as the adoption, penetration, sustainability, fidelity and cost of the programme with a mixed-methods theory-based and economic evaluation. Data will include numbers of normal, abnormal and uninterpretable SPLASH echocardiograms obtained, numbers of participants progressing through the cascade of care, interviews with staff and programme costs. ETHICS AND DISSEMINATION: Ethical approval has been obtained from the Human Research Ethics Committee of the NT Department of Health and Menzies School of Health Research, Darwin (HREC-2022-4479), the Western Australian Aboriginal Health Ethics Committee (HREC-1237) and the Instituto Nasional Saude Publika Timor-Leste Ethics and Technical Committee (03-UEPD/INSP-TL/V/2023). Informed consent is required to be enrolled. Study findings will be disseminated in the communities involved and submitted for publication. TRIAL REGISTRATION NUMBER: NCT06002243.

Indexed as

EchocardiographyRheumatic Heart DiseaseAustraliaChildEarly DiagnosisFemaleHumansMalePregnancyProgram EvaluationTimor-Lestehealth workforceimplementation sciencepublic health

Identifiers

PMID39424380
PMCPMC11492941

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.