ArticleBiomacromolecules2024
A Glycopolymer Sensor Array That Differentiates Lectins and Bacteria.
Article in Biomacromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Coordination-cage-templated multivalent glycan arrays: effects of mixed-glycan composition and chain length on lectin binding.Chemical science · 2026Article
- Multiplexed nanophotonic sensor arrays for time-resolved biomolecular analysis.Biosensors & bioelectronics · 2026Article
- Peering Through the Polymer: Tracking Small Molecules to Improve Polymer Development.Macromolecules · 2026Article
- Plasmonic glyco-nanoparticles for single-test multiplexed detection and differentiation of cancer cells.Nanoscale · 2026Article
- A Sensitive Multichannel Fluorescent Polymer Sensor Array for the Detection of Protein Fluctuations in Serum.Sensors (Basel, Switzerland) · 2026Article
- Identifying Pathoadaptation inACS sensors · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Identification of bacterial lectins offers an attractive route to the development of new diagnostics, but the design of specific sensors is complicated by the low selectivity of carbohydrate-lectin interactions. Here we describe a glycopolymer-based sensor array which can identify a selection of lectins with similar carbohydrate recognition preferences through a pattern-based approach. Receptors were generated using a polymer scaffold functionalized with an environmentally sensitive fluorophore, along with simple carbohydrate motifs. Exposure to lectins induced changes in the emission profiles of the receptors, enabling the discrimination of analytes using linear discriminant analysis. The resultant algorithm was used for lectin identification across a range of concentrations and within complex mixtures of proteins. The sensor array was shown to discriminate different strains of pathogenic bacteria, demonstrating its potential application as a rapid diagnostic tool to characterize bacterial infections and identify bacterial virulence factors such as production of adhesins and antibiotic resistance.
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Registered trials
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