Evidence map›Paper›PMID 39424112›Full record

ArticleThe journal of pain2025

The effects of neighborhood disadvantage and adverse childhood experiences on conditioned pain modulation in adults with chronic low back pain.

Pavithra A Thomas, Paige Van Ditta, Samantha Q Stocking, Caroline Webb, Samantha M Meints, Michael A Owens, Tammie Quinn, Edwin N Aroke, Matthew C Morris, Robert E Sorge and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03338192 (Racial and Socioeconomic Differences in Chronic Low Back Pain), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03338192 completednot on this map

Racial and Socioeconomic Differences in Chronic Low Back Pain

TypeobservationalSponsorUniversity of Alabama at BirminghamRan2017 to 2024Enrolled281ConditionsBack Pain Lower Back ChronicArmsQST
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pavithra A ThomasCollege of Arts and Science, Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35205, USA. Electronic address: pavithra@uab.edu.
Paige Van DittaCollege of Arts and Science, Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Samantha Q StockingCollege of Arts and Science, Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Caroline WebbCollege of Arts and Science, Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Samantha M MeintsPerioperative and Pain Medicine, Department of Anesthesiology, Brigham and Woman's Hospital, 75 Francis Street, Boston, MA 02411, USA; Harvard Medical School, Boston, MA 02115, USA.
Michael A OwensDepartment of Psychiatry and Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Tammie QuinnCollege of Arts and Science, Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Edwin N ArokeSchool of Nursing, Nurse Anesthesia Program, Department of Acute, Chronic, & Continuing Care, University of Alabama at Birmingham, Birmingham, AL, USA.
Matthew C MorrisVanderbilt University Medical Center, Department of Anesthesiology, Nashville, TN 37232, USA.
Robert E SorgeCollege of Arts and Science, Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Burel R GoodinCollege of Arts and Science, Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35205, USA; Washington University Pain Center, Department of Anesthesiology, Washington University, St. Louis, MO 63110, USA.
Demario S OverstreetSchool of Medicine, Department of Surgery, Division of Gastrointestinal, University of Alabama at Birmingham, Birmingham, AL 35203, USA.

Funding

UAB/Tuskegee Faculty Institutional Recruitment for Sustainable Transformation (UAB/TU FIRST) Partnership (NIH U54) Travel SupplementU54CA267746 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FOUAD, MONA N. · 2021 to 2024
$12.7M
Racial and Socioeconomic Differences in Chronic Low Back PainR01MD017565 · NIMHD · WASHINGTON UNIVERSITY · PI Burel R. Goodin · 2023 to 2026
$2.7M
Racial and Socioeconomic Differences in Chronic Low Back PainR01MD010441 · NIMHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOODIN, BUREL R., SORGE, ROBERT · 2017 to 2021
$2.6M
Epigenomic and Gene Expression Signatures of Racial Differences in Chronic Low Back PainR01AR079178 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AROKE, EDWIN NGOMUEH · 2021 to 2024
$1.6M
NCI NIH HHS U54 CA267746NIAMS NIH HHS R01 AR079178NIMHD NIH HHS R01 MD010441NIMHD NIH HHS R01 MD017565
6 · The paper itself

Abstract

Chronic low back pain (cLBP) remains a major health crisis worldwide. Current conceptualizations of cLBP utilize the biopsychosocial model, yet research on social factors remains limited. Adverse childhood experiences (ACEs) are a risk factor for a variety of chronic health problems, including cLBP. However, the extent to which socioeconomic context might influence associations between ACEs and cLBP remains unclear. Socioeconomic factors such as healthcare access and living conditions, which cluster at the neighborhood level, may affect how ACEs relate to cLBP in adulthood. This study examined (1) the relationship between ACEs and conditioned pain modulation (CPM), and (2) the moderating effect of area-level deprivation index (ADI) in a sample of community-dwelling adults with cLBP. 183 adults with cLBP (53% female, 62.8% non-Hispanic Black) reported on ACEs, ADI, sociodemographics, and completed experimental testing of conditioned pain modulation (CPM). Greater ACEs were associated with a less efficient CPM response for individuals residing in low neighborhood deprivation (p < 0.01). ACEs were not significantly associated with CPM for those residing in average (p = 0.31) or high deprivation (p = 0.15). Our findings suggest that a history of ACEs is associated with diminished ability to inhibit pain, especially among individuals living in less deprived neighborhoods. The association between ACEs and CPM was weakest for the portion of our sample residing in neighborhoods with the most deprivation. People from disadvantaged backgrounds may experience numerous psychosocial stressors that hinder CPM, making it difficult to assess the specific impact of ACEs on CPM.

trial registrationThis study utilized baseline data collected as part of a parent trial titled "Examining Racial and SocioEconomic Disparities in Chronic Low Back Pain" (ERASED - ClinicalTrials.gov ID: NCT03338192). PERSPECTIVE: This study demonstrates that early life adversity is associated with abnormal endogenous pain modulation, particularly for participants who live in neighborhoods characterized by less deprivation.

Indexed as

Adverse Childhood ExperiencesChronic PainConditioning, PsychologicalLow Back PainNeighborhood CharacteristicsResidence CharacteristicsAdultAgedFemaleHumansMaleMiddle AgedObservational Studies as TopicAdverse childhood experiencesArea level deprivationChronic low back painConditioned pain modulationSocial determinants of pain

Identifiers

PMID39424112
PMCPMC11781974

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.