ArticleAmerican journal of ophthalmology2025
Associations Between Dry Eye Disease and Mental Health Conditions in the All of Us Research Program.
Article in American journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- USB-powered vs. self-heating warm compresses for meibomian gland dysfunction: A prospective randomized crossover clinical trial.PloS one · 2026Trial
- Ophthalmic and psychiatric health: the overlooked connection between ocular diseases and mental disorders.Eye (London, England) · 2026Review
- The Role of Behavioral and Psychological Interventions in Chronic Ocular Pain.Current pain and headache reports · 2026Review
- Apparent protective associations between smoking, alcohol consumption, and dry eye disease: evidence from a community-based Adult Dry Eye Cohort (ADEC) in Beijing.BMC public health · 2026Article
- The relationship between subthreshold anxiety disorder and symptoms and signs of dry eye disease.Scientific reports · 2025Article
- Prevalence of dry eye disease and its association with sleep quality and depression: a hospital-based survey in Thai population.BMJ open · 2025Article
- Prevalence of dry eye disease among indoor and outdoor workers and the impact on work productivity in the West Bank of Palestine in 2024: a cross-sectional study.BMC public health · 2025Article
- From Symptoms to Satisfaction: Optimizing Patient-Centered Care in Dry Eye Disease.Journal of clinical medicine · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeTo determine the association between dry eye disease (DED) and mental health conditions in a sociodemographically diverse nationwide population of Americans.
designCross-sectional study.
methodsWe used the National Institute of Health's All of Us Research Program database to identify 18257 participants with DED who were propensity score matched in a 1:3 ratio to participants without DED. Univariate and multivariable logistic regression models were used to assess associations between DED and mental health conditions (i.e., depressive disorders, anxiety, bipolar disorder, and schizophrenic spectrum disorder).
resultsParticipants with DED had a significantly higher prevalence of depressive disorders (31.6% vs. 10.7%; P < .001), anxiety disorders (34.8% vs. 14.7%; P < .001), bipolar disorder (5.5% vs. 2.3%; P < .001), and schizophrenia spectrum disorders (2.3% vs. 0.9%; P < .001) than controls. Adjusted for medical comorbidities (i.e., hypothyroidism, Sjögren's syndrome, systemic lupus erythematosus), participants with DED had higher odds than controls in having a depressive disorder (odds ratio [OR]: 3.47; 95% CI: 3.32-3.62), anxiety (OR: 2.74; 95% CI: 2.63-2.85), bipolar disorder (OR: 2.23; 95% CI: 2.04-2.44), and schizophrenia spectrum disorder (OR: 2.48; 95% CI: 2.17-2.84). The association between DED and mental health conditions was stronger in Black participants than White participants (OR: 3.68 vs. 3.09, P < .001).
conclusionsParticipants with DED were significantly more likely to have mental health conditions than matched participants without DED; this association was stronger in Black participants than White participants. Greater efforts should be undertaken to screen DED patients for mental health conditions, particularly in historically medically underserved populations.
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