ArticleCancer cell2025
Integrating priorities at the intersection of cancer and neuroscience.
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Article in Cancer cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
–field-weighted citation impact
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Who cites it
19 citing papers in PubMed.
- Galanin impairs tumor immunity in glioblastoma by promoting infiltration and ferroptosis resistance of myeloid-derived suppressor cells.Nature cancer · 2026Article
- Cancer Neuroscience: From Local Neuro-Immune Microenvironments to Systemic Brain-Body Circuitry.MedComm · 2026Review
- Transsynaptic tracing techniques to interrogate neuronal connectivity of glioblastomas.Nature protocols · 2026Review
- Chronic stress disrupts hepatic homeostasis and accelerates liver cancer progression through ADRB2 signaling.Science advances · 2026Article
- The neuro-vascular-immune triad: the interactive network in the tumor microenvironment.Cell communication and signaling : CCS · 2026Review
- The influence of neuro-tumor interactions on tumorigenesis and therapeutic response.Experimental hematology & oncology · 2026Review
- Exploration of precise classification and therapeutic targets of breast cancer based on genes related to neuro-cancer crosstalk.Translational oncology · 2026Article
- Critical role of cell competition in gliomagenesis.bioRxiv : the preprint server for biology · 2026Article
- Neural regulation of immune evasion in breast cancer: a multiscale neuro-immune framework.Frontiers in immunology · 2026Review
- Peripheral Nerve-Cancer Interactions in the Tumor Microenvironment: A Three-Dimensional Framework Integrating Mechanisms, Modulators, and Therapeutic Strategies.Research (Washington, D.C.) · 2026Review
- The neural niche in cancer: mechanistic insights into tumor-neuron-immune crosstalk and therapeutic opportunities.Frontiers in cell and developmental biology · 2026Review
- Immunotherapy and targeted therapy for high grade gliomas: current and future directions.Journal of neuro-oncology · 2025Review
- Neuropeptide adrenomedullin remodels stemness and macrophage dynamics in glioblastoma.Cell reports · 2025Article
- Neuro-Cancer Interactions Shape Glioma Intratumoral Heterogeneity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- OPIOID-EXPRESSING B CELLS SILENCE TUMOR-INFILTRATING NOCICEPTOR NEURONS.Research square · 2025Article
- Bioinformatics Screening of Tumor-Derived Neuropeptides Mediating Neuroimmune Axis of Head and Neck Cancer.Cancers · 2025Article
- Sympathetic axonogenesis promotes adenoid cystic carcinoma progression.The Journal of experimental medicine · 2025Article
- GABRP Mediates GABA-A Receptor to Shape Tumor Immunosuppressive Microenvironment and Promote Tumor Immune Escape and Corresponding Targeted Therapy.Cancer medicine · 2025Article
- Electrophysiology of gliomas: current science, implications, and opportunities.Frontiers in oncology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors.
William L HwangCenter for Systems Biology, Center for Cancer Research, and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA. Electronic address: whwang1@mgh.harvard.edu.
Ella N PerraultCenter for Systems Biology, Center for Cancer Research, and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA; Program in Neuroscience, Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Alexander BirbrairDepartment of Dermatology, Carbone Cancer Center, and Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, USA.
Brandi J MattsonThe Belfer Neurodegeneration Consortium, Therapeutics Discovery Division, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
David H GutmannDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Donald J MabbottNeurosciences and Mental Health Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.
Edna CukiermanFox Chase Cancer Center, Temple Health, Philadelphia, PA, USA; Tumor Microenvironment Working Group, American Association for Cancer Research, Philadelphia, PA, USA.
Elizabeth A RepaskyDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Erica K SloanMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Hui ZongDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Ihsan Ekin DemirDepartment of Surgery, TUM University Hospital, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; Else Kröner Clinician Scientist Professor, Munich, Germany.
Jami L SalomanDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Jeremy C BornigerCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Jian HuDepartment of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jorg DietrichDepartment of Neurology, Center for Neuro-Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Joshua J BreunigDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Kaan ÇifcibaşıDepartment of Surgery, TUM University Hospital, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Khalil Ali Ahmad KasmDepartment of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Manuel ValienteBrain Metastasis Group, CNIO, Madrid, Spain.
Max WintermarkDepartment of Neuroradiology, MD Anderson Cancer Center, Houston, TX, USA.
Munjal M AcharyaDepartment of Anatomy and Neurobiology, University of California at Irvine, Irvine, CA, USA.
Nicole N ScheffDepartment of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Nisha J D'SilvaDepartment of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Paola D VermeerCancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, SD, USA.
Richard J WongDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sebastien TalbotDepartment of Physiology and Pharmacology, Karolinska Institute, Solna, Sweden; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
Shawn L Hervey-JumperDepartment of Neurosurgery and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Timothy C WangDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Yi YeTranslational Research Center, Pain Research Center, Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA.
Yuan PanDepartment of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yuri L BunimovichDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Moran AmitDepartment of Head and Neck Surgery and the Department of Genomic Medicine, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA; University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. Electronic address: mamit@mdanderson.org.
Funding
WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8MSingle-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9MUniv.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9MThe Role of Stem Cells and the Microenvironment in Gastrointestinal CancersR35CA210088 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2017 to 2026
$10.2MDefining the Role of Tumor-Neutral Crosstalk in head and Neck Cancer Progression and Treatment ResistanceR37CA242006 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMIT, MORAN · 2020 to 2025
$3.4MPancreatic Cancer-Associated Fibroblasts: Function, Detection, and RegulationR01CA269660 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Edna Cukierman · 2022 to 2026
$3.1MPeripheral Nerve Regulation of Pancreas Cancer ProgressionR01CA285585 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jami Lynn Saloman · 2024 to 2026
$1.9MIntra-tumoral neurons contribute to head and neck cancer painR01DE032712 · NIDCR · SANFORD RESEARCH/USD · PI Paola Drapkin Vermeer · 2023 to 2026
$1.8MElucidating cancer-intrinsic mechanisms of perineural invasion in pancreatic cancerK08CA270417 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI William L Hwang · 2022 to 2026
$1.6MCancer Neuroscience - An Emerging HallmarkR13CA287350 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMIT, MORAN, MONTANO, MONTY A · 2024 to 2024
$15kNCI NIH HHS K08 CA270417NCI NIH HHS P30 CA006927NCI NIH HHS P30 CA045508NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA269660NCI NIH HHS R01 CA285585NCI NIH HHS R13 CA287350NCI NIH HHS R35 CA210088NCI NIH HHS R37 CA242006NIDCR NIH HHS R01 DE032712
Abstract
Cancer neuroscience is a rapidly growing multidisciplinary field that conceptualizes tumors as tissues fully integrated into the nervous system. Recognizing the complexity and challenges in this field is of fundamental importance to achieving the goal of translational impact for cancer patients. Our commentary highlights key scientific priorities, optimal training settings, and roadblocks to translating scientific findings to the clinic in this emerging field, aiming to formulate a transformative and cohesive path forward.
Indexed as
NeoplasmsNeurosciencesHumansTranslational Research, Biomedical
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