Evidence map›Paper›PMID 39423805›Full record

ArticleCell2024

Pioneering discovery and therapeutics at the brain-vascular-immune interface.

Katerina Akassoglou, Dimitrios Davalos, Andrew S Mendiola, Mark A Petersen, Jae Kyu Ryu, Christian Schachtrup, Zhaoqi Yan

Abstract read
In one paragraph

Article in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
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  4. CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katerina AkassoglouCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA 94158, USA; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: kakassoglou@gladstone.ucsf.edu.
Dimitrios DavalosDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA.
Andrew S MendiolaDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
Mark A PetersenCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA 94158, USA; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA.
Jae Kyu RyuCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA 94158, USA; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Christian SchachtrupInstitute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Zhaoqi YanCenter for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA 94158, USA; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.

Funding

Neurovascular Interactions: Mechanisms, imaging, therapeutic potentialR35NS097976 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI AKASSOGLOU, KATERINA · 2016 to 2023
$11.1M
MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
Gliovascular Mechanisms of Blood-Brain Barrier Disruption in Neuroinflammatory DiseaseR01NS112526 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI DAVALOS, DIMITRIOS · 2019 to 2023
$2.4M
Epigenomic regulation of oxidative stress-producing innate immunity in neuroinflammationR00NS126707 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrew S Mendiola · 2024 to 2026
$706k
OPC-X screen: Discovery of small molecule inhibitors to overcome extrinsic inhibition of remyelination.R61NS133257 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI AKASSOGLOU, KATERINA · 2024 to 2024
$458k
Epigenomic regulation of oxidative stress-producing innate immunity in neuroinflammationK99NS126707 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI MENDIOLA, ANDREW S · 2022 to 2023
$242k
NIAID NIH HHS T32 AI007334NINDS NIH HHS K99 NS126707NINDS NIH HHS R01 NS112526NINDS NIH HHS R35 NS097976NINDS NIH HHS R61 NS133257
6 · The paper itself

Abstract

The brain-vascular-immune interface has emerged as a dynamic player in brain physiology and disease. We propose integrating vascular risk factors with genetic susceptibility as the nexus for the discovery of mechanisms and therapies for neuroinflammation, neurodegeneration, and neurorepair across polygenic neurologic diseases.

Indexed as

BrainNeuroinflammatory DiseasesAnimalsGenetic Predisposition to DiseaseHumans

Identifiers

PMID39423805
PMCPMC13046387

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.