ArticleScience advances2024
Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis.
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Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
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Who cites it
26 citing papers in PubMed.
- Diabetes-Associated Cognitive Impairment: Pathophysiology and Emerging Therapies.Annals of clinical and translational neurology · 2026Review
- Solute carrier membrane transporters: emerging targets in CNS disorders.Nature reviews. Drug discovery · 2026Review
- Female-specific alterations in insulin dynamics are associated with glucose tolerance in a Glut1DS mouse model.Disease models & mechanisms · 2026Article
- Single-cell profiling identifies obesity-disrupted brain glucose sensing.Nature communications · 2026Article
- Brain insulin resistance as a driver of proteinopathy in neurodegeneration: from cell-type-specific mechanisms to targeted therapeutics.Translational neurodegeneration · 2026Review
- Glucose Transporter 1 in Health and Disease.MedComm · 2026Review
- Enhancing pulp regeneration through metabolic reprogramming of mature dental pulp stem cells mediated by GLUT1/HK2 mRNA delivery.International journal of oral science · 2026Article
- Multi-functionalized chitosan-Extracellular vesicles nanohybrid system for intranasal delivery of pApoE2 to attenuate age-related inflammation.International journal of biological macromolecules · 2026Article
- Hypothalamic astrocytes: connecting brain and periphery in metabolic control.Reviews in endocrine & metabolic disorders · 2026Review
- An engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling.Science advances · 2026Article
- Contribution of metabolism-independent glucose sensing to metabolic homeostasis.Trends in endocrinology and metabolism: TEM · 2026Review
- The rise of astrocytes: are they guardians or troublemakers of the brain disorder?Experimental & molecular medicine · 2026Review
- Metabolic regulation by tanycyte-derived extracellular vesicles through insulin precursor-mediated neuronal recognition and mTORC component delivery.Nature metabolism · 2026Article
- The Molecular Signature of Astrocyte Response to Hypoxia Outlines the Metabolic and Cell Survival Mechanisms for Neuroprotection.Neurochemical research · 2026Article
- Vacuolar protein sorting 35 regulates retinal neurovascular functionInternational journal of ophthalmology · 2026Article
- Acupuncture regulates neuroinflammation: microglial glucose metabolism reprogramming as a potential mediating mechanism.Frontiers in immunology · 2026Review
- Article
- 20-hydroxyecdysone promotes brain development via upregulating MMP2 expression during metamorphosis in Helicoverpa armigera.PLoS genetics · 2026Article
- Astrocytes in systemic regulation of blood glucose and the development of type 2 diabetes.Frontiers in cellular neuroscience · 2026Review
- ATP Metabolism of Astrocytes: Consumption, Regeneration and Restoration.Neurochemical research · 2025Review
Corrections and comments
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Authors and funding
21 authors.
Carlos G ArdanazDepartment of Pharmaceutical Sciences, Division of Pharmacology, University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0001-5328-2986
Aida de la CruzLaboratory of Local Translation in Neurons and Glia, Achucarro Basque Centre for Neuroscience, 48940 Leioa, Spain.ORCID 0000-0002-6039-8263
Paras S MinhasDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-7741-3327
Nira Hernández-MartínUnidad de Cartografía Cerebral, Instituto Pluridisciplinar, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0009-0009-3933-1804
Miguel Ángel PozoUnidad de Cartografía Cerebral, Instituto Pluridisciplinar, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0001-9303-0513
M Pilar ValdecantosInstituto de Investigaciones Biomédicas Sols-Morreale, CSIC-UAM, Department of Metabolism and Cellular Signaling, Madrid 28029, Spain.ORCID 0000-0002-3239-4898
Ángela M ValverdeInstituto de Investigaciones Biomédicas Sols-Morreale, CSIC-UAM, Department of Metabolism and Cellular Signaling, Madrid 28029, Spain.ORCID 0000-0003-1192-9045
Palmira Villa-ValverdeICTS Bioimagen Complutense, Universidad Complutense de Madrid, Madrid, Spain.ORCID 0000-0001-9054-9176
Marcos Elizalde-HorcadaInstitut d'Investigació Sanitaria Pere Virgili (IISPV), 43204 Reus, Spain.
Elena PuertaDepartment of Pharmaceutical Sciences, Division of Pharmacology, University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0001-5695-5787
María J RamírezDepartment of Pharmaceutical Sciences, Division of Pharmacology, University of Navarra, 31008 Pamplona, Spain.
Jorge E OrtegaCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.ORCID 0000-0001-8188-874X
Ainhoa UrbiolaIdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
Cristina EderraIdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.ORCID 0009-0003-9876-4657
Mikel ArizIdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.ORCID 0000-0002-7328-1582
Carlos Ortiz-de-SolórzanoIdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.ORCID 0000-0001-8720-0205
Joaquín Fernández-IrigoyenProteomics Platform, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), IdiSNA, 31008 Pamplona, Spain.ORCID 0000-0001-5072-4099
Enrique SantamaríaClinical Neuroproteomics Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), IdiSNA, 31008 Pamplona, Spain.ORCID 0000-0001-8046-8102
Gerard KarsentyDepartment of Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY, USA.ORCID 0000-0002-9253-7627
Jens C BrüningMax Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism, 50931 Cologne, Germany.ORCID 0000-0002-6619-0092
Maite SolasDepartment of Pharmaceutical Sciences, Division of Pharmacology, University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0001-7670-3237
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MNCI NIH HHS P30 CA008748
Abstract
Astrocytes are considered an essential source of blood-borne glucose or its metabolites to neurons. Nonetheless, the necessity of the main astrocyte glucose transporter, i.e., GLUT1, for brain glucose metabolism has not been defined. Unexpectedly, we found that brain glucose metabolism was paradoxically augmented in mice with astrocytic GLUT1 reduction (GLUT1
Indexed as
AstrocytesBrainGlucoseGlucose Transporter Type 1HomeostasisAdenosine TriphosphateAnimalsEnergy MetabolismInsulinMiceMice, KnockoutObesityReceptor, InsulinSignal TransductionAdenosine TriphosphateGlucoseGlucose Transporter Type 1InsulinReceptor, InsulinSlc2a1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.