Evidence map›Paper›PMID 39423260›Full record

ArticleScience advances2024

Altruistic feeding and cell-cell signaling during bacterial differentiation actively enhance phenotypic heterogeneity.

Taylor B Updegrove, Thomas Delerue, Vivek Anantharaman, Hyomoon Cho, Carissa Chan, Thomas Nipper, Hyoyoung Choo-Wosoba, Lisa M Jenkins, Lixia Zhang, Yijun Su and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. A lipid cue drives the subcellular localization of a self-inserting bacterial transmembrane protein.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Monitoring of the Single-Cell Behavior of anBiotech (Basel (Switzerland)) · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Taylor B UpdegroveLaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-9763-3618
Thomas DelerueLaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8900-247X
Vivek AnantharamanComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8395-0009
Hyomoon ChoLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-3447-8726
Carissa ChanLaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-3054-0879
Thomas NipperLaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-5307-2927
Hyoyoung Choo-WosobaOffice of Collaborative Biostatistics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Lisa M JenkinsLaboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-1245-1338
Lixia ZhangAdvanced Imaging and Microscopy Resource, National Institutes of Health, Bethesda, MD, USA.
Yijun SuLaboratory of High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA.
Hari ShroffLaboratory of High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-3613-8215
Jiji ChenAdvanced Imaging and Microscopy Resource, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-4426-3035
Carole A BewleyLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-2203-0852
L AravindComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0771-253X
Kumaran S RamamurthiLaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-2335-3568

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Starvation triggers bacterial spore formation, a committed differentiation program that transforms a vegetative cell into a dormant spore. Cells in a population enter sporulation nonuniformly to secure against the possibility that favorable growth conditions, which put sporulation-committed cells at a disadvantage, may resume. This heterogeneous behavior is initiated by a passive mechanism: stochastic activation of a master transcriptional regulator. Here, we identify a cell-cell communication pathway containing the proteins ShfA (YabQ) and ShfP (YvnB) that actively promotes phenotypic heterogeneity, wherein

Indexed as

Bacillus subtilisBacterial ProteinsGene Expression Regulation, BacterialPhenotypeSignal TransductionSpores, BacterialCell CommunicationBacterial Proteins

Identifiers

PMID39423260
PMCPMC11488536

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.