Article in Journal of immunology (Baltimore, Md. : 1950), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors.
Suganya KanmaniDepartment of Anesthesiology, University of Illinois College of Medicine, Chicago, IL.
Xue-Min SongDepartment of Anesthesiology, University of Illinois College of Medicine, Chicago, IL.
Paulraj KanmaniDepartment of Anesthesiology, University of Illinois College of Medicine, Chicago, IL.
Xiao-Jing WuDepartment of Anesthesiology, University of Illinois College of Medicine, Chicago, IL.
Xiao-Di TanDepartment Pediatrics, University of Illinois College of Medicine, Chicago, IL.ORCID 0000-0003-3766-5885
Jing LiuDepartment of Surgery/Cancer Center, University of Illinois College of Medicine, Chicago, IL.
Ji-Ping WangDepartments of Statistics and Data Science, Northwestern University, Evanston, IL; and.ORCID 0000-0002-8398-939X
Richard D MinshallDepartment of Anesthesiology, University of Illinois College of Medicine, Chicago, IL.ORCID 0000-0003-3164-475X
Guochang HuDepartment of Anesthesiology, University of Illinois College of Medicine, Chicago, IL.
Funding
Role Of p120 Catenin In Sepsis-Induced Lung InjuryR01HL104092 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HU, GUOCHANG · 2010 to 2020
$3.9M
Insights into a multi-hit process in the development of necrotizing enterocolitisR01DK129960 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TAN, XIAO-DI · 2022 to 2025
$2.6M
Mechanisms underlying regulation of intestinal epithelial homeostasis in sepsisR01DK123826 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TAN, XIAO-DI · 2020 to 2023
$2.4M
Fibroblast Mediated Mechanisms of Pulmonary HypertensionR01HL142636 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MINSHALL, RICHARD D · 2019 to 2023
$2.0M
Surgical studies of gut epithelial apoptosis-initiated critical illnessR01GM117628 · NIGMS · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI TAN, XIAO-DI · 2016 to 2019
$1.9M
ER-phagy regulation of immune response: mechanisms and significanceR01HL173334 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Guochang Hu · 2024 to 2026
$1.8M
Targeting the host immune response during sepsisR01HL152696 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HU, GUOCHANG · 2020 to 2023
$1.8M
Role of sumoylation in vascular endothelial barrier dysfunction in sepsisR21AI152249 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HU, GUOCHANG · 2020 to 2021
$440k
Mechanisms of trauma and hemorrhage-induced impairment of innate immunityI01BX001690 · VA · JESSE BROWN VA MEDICAL CENTER · PI TAN, XIAO-DI · 2013 to 2016
–
BLRD VA I01 BX001690BLRD VA I01 BX006085HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL104092HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL152696HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI152249HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK123826HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM117628HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK129960NHLBI NIH HHS R01 HL104092NHLBI NIH HHS R01 HL142636NHLBI NIH HHS R01 HL152696NHLBI NIH HHS R01 HL173334NIAID NIH HHS R21 AI152249NIDDK NIH HHS R01 DK123826NIDDK NIH HHS R01 DK129960NIGMS NIH HHS R01 GM117628US Department of Veterans Affairs Merit Review Award I01BX001690
6 · The paper itself
Abstract
Autophagy serves as a critical regulator of immune responses in sepsis. Macrophages are vital constituents of both innate and adaptive immunity. In this study, we delved into the intricate role of p120-catenin (p120) in orchestrating autophagy in macrophages in response to endotoxin stimulation. Depletion of p120 effectively suppressed LPS-induced autophagy in both J774A.1 macrophages and murine bone marrow-derived macrophages. LPS not only elevated the interaction between p120 and L chain 3 (LC3) I/II but also facilitated the association of p120 with mammalian target of rapamycin (mTOR). p120 depletion in macrophages by small interfering RNA reduced LPS-induced dissociation of mTOR and Unc-51-like kinase 1 (ULK1), leading to an increase in the phosphorylation of ULK1. p120 depletion also enhanced LPS-triggered macrophage apoptosis, as evidenced by increased levels of cleaved caspase 3, 7-aminoactinomycin D staining, and TUNEL assay. Notably, inhibiting autophagy reversed the decrease in apoptosis caused by LPS stimulation in macrophages overexpressing p120. Additionally, the ablation of p120 inhibited autophagy and accentuated apoptosis in alveolar macrophages in LPS-challenged mice. Collectively, our findings strongly suggest that p120 plays a pivotal role in fostering autophagy while concurrently hindering apoptosis in macrophages, achieved through modulation of the mTOR/ULK1 signaling pathway in sepsis. This underscores the potential of targeting macrophage p120 as an innovative therapeutic avenue for treating inflammatory disorders.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Enhancement of Autophagy in Macrophages via the p120-Catenin-Mediated mTOR Signaling Pathway. · full record | OpenQuestion