Evidence map›Paper›PMID 39423036›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

Load-dependent mechanisms contribute to increased aortic stiffness among women with a history of preeclampsia: relation with cardiovagal baroreflex sensitivity.

Kristen G Davis, Matthew K Armstrong, Virginia R Nuckols, Meaghan N Smith, Ryan Pewowaruk, Colin J Gimblet, Donna A Santillan, Mark K Santillan, Gary L Pierce

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Beneficial vascular effects of oral phosphatidylserine supplementation in type 2 diabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2026
    Trial
  2. ENAC blockade reduces blood pressure and arterial stiffness in adults with obesity and insulin resistance.American journal of physiology. Heart and circulatory physiology · 2026
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristen G DavisDepartment of Health and Human Physiology, University of Iowa, Iowa City, Iowa, United States.ORCID 0009-0009-0372-207X
Matthew K ArmstrongDepartment of Health and Human Physiology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0002-3948-2452
Virginia R NuckolsDepartment of Health and Human Physiology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0001-5879-5991
Meaghan N SmithDepartment of Health and Human Physiology, University of Iowa, Iowa City, Iowa, United States.
Ryan PewowarukRyan Pewowaruk Consulting, Madison, Wisconsin, United States.ORCID 0000-0003-1190-7196
Colin J GimbletDepartment of Health and Human Physiology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0002-3024-2284
Donna A SantillanDepartment of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0002-6180-9714
Mark K SantillanDepartment of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa, United States.
Gary L PierceDepartment of Health and Human Physiology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0001-7499-080X

Funding

University of Iowa Institute for Clinical and Translational ScienceUM1TR004403 · NCATS · UNIVERSITY OF IOWA · PI Marlan R Hansen, Patricia Winokur · 2023 to 2026
$16.1M
University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)P50HD103556 · NICHD · UNIVERSITY OF IOWA · PI EDWIN TED G. ABEL, Lane Strathearn · 2021 to 2026
$8.5M
Training Program in Hypertension, Kidney Disease & Cell BiologyT32DK007690 · NIDDK · UNIVERSITY OF IOWA · PI HUANG, CHOU-LONG, RAHMOUNI, KAMAL · 1992 to 2022
$2.8M
American Heart Association (AHA) 18SCG34350001American Heart Association (AHA) 969732NCATS NIH HHS UM1 TR004403NICHD NIH HHS P50 HD103556NIDDK NIH HHS T32 DK007690
6 · The paper itself

Abstract

Preeclampsia, a hypertensive disorder of pregnancy, results in increased lifetime cardiovascular disease (CVD) risk. Total aortic stiffness, a robust risk factor for CVD, is composed of load-dependent (blood pressure load on arterial wall) and structural (intrinsic changes in arterial wall) mechanisms. Total aortic stiffness is also associated with reduced cardiovagal baroreflex sensitivity (BRS). We sought to determine

Indexed as

BaroreflexPre-EclampsiaVagus NerveVascular StiffnessAdultBlood PressureCarotid-Femoral Pulse Wave VelocityCase-Control StudiesFemaleHeart RateHumansPregnancyPulse Wave Analysisautonomicblood pressurecardiovascular diseasehypertensionpregnancy

Identifiers

PMID39423036
PMCPMC11684942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.