Evidence map›Paper›PMID 39423024›Full record

ArticleInternational journal of immunopathology and pharmacology

SMC4 serves as a potential marker for the diagnosis and prognosis of colon adenocarcinoma.

Dawei Yang, Wenxin Cheng, Ying Liu, Liang Ma, Yao Sun, Hongzhen Wang, Haifeng Liu, Li Nan, Yang Yang, Xinyue Wang

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In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Dawei YangDepartment of General Surgery, Siping Central People's Hospital, Siping, Jilin, China.
Wenxin ChengDepartment of Surgery, Chinese Medical Sciences University, Shenyang, Liaoning, China.
Ying LiuKey Laboratory of Pathobiology (Yanbian University), State Ethnic Affairs Commission, Yanji, Jilin, China.
Liang MaDepartment of General Surgery, Siping Central People's Hospital, Siping, Jilin, China.
Yao SunDepartment of General Surgery, Siping Central People's Hospital, Siping, Jilin, China.
Hongzhen WangLife Science Academy, Jilin Normal University, Siping, China.
Haifeng LiuDepartment of General Surgery, Siping Central People's Hospital, Siping, Jilin, China.
Li NanInstitute of Virology, Wenzhou University, Wenzhou, China.
Yang YangKey Laboratory of Pathobiology (Yanbian University), State Ethnic Affairs Commission, Yanji, Jilin, China.
Xinyue WangKey Laboratory of Pathobiology (Yanbian University), State Ethnic Affairs Commission, Yanji, Jilin, China.ORCID 0000-0002-8634-9590

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aimed to explore the role of structural maintenance of chromosomes 4 (SMC4) in malignant progression and immunology of colon adenocarcinoma (COAD).

methodsThe expression, genetic and protein features, and immune cell infiltration of SMC4 in pan-cancer were provided by public databases and websites. The protein expression of SMC4 in COAD tissues was screened by immunohistochemical assay. Si-RNA-mediated transfection was performed in COAD cells and the proliferation viability was measured using MTT, colony formation and EdU assays. Cell autophagy was detected by AO staining, western blots, and immunofluorescence staining. The migratory ability was determined using scratch and transwell assays. The expression of epithelial-to-mesenchymal transition (EMT) markers and transcriptional factors were detected using western blots.

resultsThe expression of SMC4 was upregulated in pan-cancer and had relationships with prognosis, TMB, and MSI of cancer patients. Particularly, SMC4 protein was highly expressed in COAD tissues and correlated with poor prognosis of patients. Depletion of SMC4 inhibited cell proliferation, induced autophagy, and decreased migration through EMT progression in COAD cells. In addition, SMC4 was associated with infiltration of neutrophils, M2 macrophages, and CD4 + T cells in COAD, and had positive association with M2 macrophage markers and immune checkpoints.

conclusionSMC4 was correlated with patients' poor prognosis, proliferation, metastasis, and immune cell infiltrates, and might function as a potential diagnosis and prognostic biomarker in COAD.

Indexed as

AdenocarcinomaBiomarkers, TumorCell Cycle ProteinsCell MovementCell ProliferationColonic NeoplasmsEpithelial-Mesenchymal TransitionAdenosine TriphosphatasesAutophagyCell Line, TumorChromosomal Proteins, Non-HistoneFemaleHumansMalePrognosisUp-RegulationAdenosine TriphosphatasesBiomarkers, TumorCell Cycle ProteinsChromosomal Proteins, Non-HistoneSMC4 protein, humanbiomarkercolon adenocarcinomaepithelial-to-mesenchymal transitionimmune infiltrationstructural maintenance of chromosomes 4

Identifiers

PMID39423024
PMCPMC11490969

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