Evidence map›Paper›PMID 39422841›Full record

ArticleJournal of cardiovascular translational research2025

Shorter Leukocyte Telomere Length Is Associated with Increased Major Adverse Cardiovascular Events or Mortality in Patients with Essential Hypertension.

Hongna Fu, Yuanting Zhu, Luyang Lin, Peng Jiang, Guoyi Cai, Lijin Zeng, Xinyu Li, Yuchun Zhang, Chunhao Li, Hong Zhan and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hongna Fu *Division of Emergency Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.
Yuanting Zhu *NHC Key Laboratory of Assisted Circulation and Vascular Diseases, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.
Luyang Lin *Division of Emergency Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.
Peng Jiang *Division of Emergency Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.
Guoyi CaiDivision of Emergency Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.
Lijin ZengDivision of Emergency Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.
Xinyu LiDivision of Emergency Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.
Yuchun ZhangFood Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou, 510515, P. R. China.
Chunhao LiFood Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou, 510515, P. R. China.
Hong ZhanDivision of Emergency Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China. zhanhong@mail.sysu.edu.cn.
Bo ZhangFood Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou, 510515, P. R. China. zhangbo2018@smu.edu.cn.
Zhen YangDivision of Emergency Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China. yangzh8@mail.sysu.edu.cn.ORCID 0000-0001-5823-7949

Funding

Dongguan Science and Technology of Social Development Program 20221800906192National Natural Science Foundation of China 82171578Science and Technology Project of Guangzhou City 2023B03J0121
6 · The paper itself

Abstract

The association between leukocyte telomere length (LTL) alteration and major adverse cardiovascular events (MACE) or mortality in patients with hypertension is still unclear. 20,034 patients with essential hypertension were enrolled from UK biobank. Multivariable COX regression models were performed to assess the association. LTL was shorter in hypertensive patients with MACE compared to those without MACE. Hypertensive patients in the lowest LTL quartile were at higher risk to develop MACE (adjusted HR 1.15 [95% CI 1.02-1.29], vs top LTL quartile, p-trend = 0.03). Similarly, shorter LTL was related with increased mortality (adjusted HR 1.18[95% CI 1.06-1.3], lowest vs top LTL quartile, p-trend < 0.001). This investigation demonstrated that shorter LTL is associated with increased risk of MACE or mortality in patients with essential hypertension, which indicates that LTL may be a potential predictor of prognosis or underlying therapeutic target for hypertension.

Indexed as

Blood PressureEssential HypertensionLeukocytesTelomereTelomere HomeostasisTelomere ShorteningAgedFemaleHumansMaleMiddle AgedPrognosisRisk AssessmentRisk FactorsTime FactorsHypertensionLarge sample cohort studyMajor adverse cardiovascular eventsMortalityTelomere length

Identifiers

PMID39422841

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.