Evidence map›Paper›PMID 39422775›Full record

ArticleVirchows Archiv : an international journal of pathology2025

Primary central nervous system diffuse large B-cell lymphoma with MYC and BCL2 rearrangements associated with deep brain stimulation device.

Kirill A Lyapichev, Sri Bharathi Kavuri, Patrick J Karas, Laura Wu, Nahyun Jo, John Heymann, Hadi Yaziji, Jianli Dong, Farkhod Tursunbaev, Rasha Alfattal and 1 more

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Kirill A Lyapichev *Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA. kirill.lyapichev@gmail.com.ORCID http://orcid.org/0000-0001-9983-9735
Sri Bharathi Kavuri *Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Patrick J KarasDepartment of Neurosurgery, University of Texas Medical Branch, Galveston, TX, USA.
Laura WuDepartment of Neurology, University of Texas Medical Branch, Galveston, TX, USA.
Nahyun JoDepartment of Radiology, University of Texas Medical Branch, Galveston, TX, USA.
John HeymannDepartment of Radiology, University of Texas Medical Branch, Galveston, TX, USA.
Hadi YazijiVitro Molecular Laboratories, Miami, FL, USA.
Jianli DongDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Farkhod TursunbaevDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Rasha AlfattalDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Michelle Madden FelicellaDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary central nervous system (CNS) diffuse large B-cell lymphoma with MYC and BCL2 rearrangements is a very rare lymphoma subtype. Deep brain stimulation is an effective minimally invasive therapeutic option for the treatment of refractory movement disorders, as well as some psychiatric disorders and chronic pain syndromes. Herein, we report a case of CNS lymphoma, which developed around an electrode of a deep brain stimulation (DBS) device. A 70-year-old woman with drug-resistant essential tremor was treated with bilateral thalamic DBS with significant symptomatic improvement over the following year. She presented to the emergency department with recurrent tremor, blurred vision, and confusion. Imaging showed a 4 cm heterogeneously enhancing centered around the DBS electrode. Pathologic evaluation and systemic workup confirmed a diagnosis of primary CNS diffuse large B-cell lymphoma. MYC and BCL2 rearrangements were identified. To our knowledge, this is the first reported case of a CNS lymphoma associated with a DBS electrode.

Indexed as

Central Nervous System NeoplasmsDeep Brain StimulationGene RearrangementLymphoma, Large B-Cell, DiffuseProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mycAgedFemaleHumansBCL2 protein, humanMYC protein, humanProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mycCNSDBSDiffuse large B-cell lymphoma with MYC and BCL2 rearrangements

Identifiers

PMID39422775

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.