Evidence map›Paper›PMID 39422746›Full record

SynthesisNaunyn-Schmiedeberg's archives of pharmacology2025

Preclinical studies of natural flavonoids in inflammatory bowel disease based on macrophages: a systematic review with meta-analysis and network pharmacology.

Shasha Shi, Hao Jiang, Wenke Ma, Zitong Guan, Mengxue Han, Shuai Man, Zhuzhu Wu, Shan He

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shasha ShiPharmacy School, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
Hao JiangPharmacy School, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
Wenke MaInnovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
Zitong GuanInnovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
Mengxue HanInnovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
Shuai ManExperimental Center, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. 13615422589@163.com.
Zhuzhu WuKey Laboratory of Traditional Chinese Medicine for Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. 825684873@qq.com.
Shan HePharmacy School, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. heshan0627@163.com.

Funding

Natural Science Foundation of Shandong Province of China ZR2022QH185
6 · The paper itself

Abstract

Flavonoid is a category of bioactive polyphenolic compounds that are extensively distributed in plants with specific pharmacological properties, such as anti-inflammatory and anti-oxidant. Importantly, natural flavonoids have shown the protected function on the dextran sulfate sodium (DSS)-induced colitis in animals and lipopolysaccharides (LPS)-induced inflammatory response in macrophages. The purpose of this systematic review is to explore the efficacy of natural flavonoids in animal models of IBD (inflammatory bowel disease) and potential mechanisms in macrophages by meta-analysis and network pharmacology in preclinical studies. Relevant foundation studies were searched from January 2010 to November 2023 in databases like PubMed, Elsevier ScienceDirect, and Web of Science. Then, OriginPro software was used to extract values from images, and the analysis was performed using Review Manager 5.3. The retrieved data was analyzed according to the fixed-effects model and random-effects model. Subsequently, heterogeneity was evaluated using the I

Indexed as

Anti-Inflammatory AgentsFlavonoidsInflammatory Bowel DiseasesMacrophagesAnimalsDisease Models, AnimalHumansNetwork PharmacologyAnti-Inflammatory AgentsFlavonoidsInflammatory bowel diseaseMacrophagesMechanismsMeta-analysisNatural flavonoidNetwork pharmacology

Identifiers

PMID39422746

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.