Evidence map›Paper›PMID 39422718›Full record

Trial reportDiabetologia2025

Fasting as an intervention to alter the impact of simulated night-shift work on glucose metabolism in healthy adults: a cluster randomised controlled trial.

Stephanie Centofanti, Leonie K Heilbronn, Gary Wittert, Jillian Dorrian, Alison M Coates, David Kennaway, Charlotte Gupta, Jacqueline M Stepien, Peter Catcheside, Crystal Yates and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. A Systematic Review of Nutrition Interventions for Shift Workers, With Subgroup Analysis of First Responder Populations.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Pooled it
  2. Pooled it
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  11. Diabetes in the Workplace: Risks and Remedies.Indian journal of endocrinology and metabolism
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Stephanie Centofanti *Behaviour-Brain-Body Research Centre, UniSA Justice and Society, University of South Australia, Adelaide, SA, Australia.
Leonie K Heilbronn *Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.ORCID 0000-0003-2106-7303
Gary WittertLifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.
Jillian DorrianBehaviour-Brain-Body Research Centre, UniSA Justice and Society, University of South Australia, Adelaide, SA, Australia.ORCID 0000-0002-6485-1643
Alison M CoatesBehaviour-Brain-Body Research Centre, UniSA Justice and Society, University of South Australia, Adelaide, SA, Australia.
David KennawayFaculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia.
Charlotte GuptaAppleton Institute, Central Queensland University, Rockhampton, QLD, Australia.
Jacqueline M StepienBehaviour-Brain-Body Research Centre, UniSA Justice and Society, University of South Australia, Adelaide, SA, Australia.
Peter CatchesideFlinders Health and Medical Research Institute: Sleep Health (formerly Adelaide Institute for Sleep Health), Flinders University, Adelaide, SA, Australia.
Crystal YatesBehaviour-Brain-Body Research Centre, UniSA Justice and Society, University of South Australia, Adelaide, SA, Australia.
Linda GrosserBehaviour-Brain-Body Research Centre, UniSA Justice and Society, University of South Australia, Adelaide, SA, Australia.
Raymond W MatthewsAppleton Institute, Central Queensland University, Rockhampton, QLD, Australia.
Siobhan BanksBehaviour-Brain-Body Research Centre, UniSA Justice and Society, University of South Australia, Adelaide, SA, Australia. siobhan.banks@unisa.edu.au.ORCID 0000-0002-7489-0929

Funding

National Health and Medical Research Council APP1099077
6 · The paper itself

Abstract

aims/hypothesisNight-shift work causes circadian misalignment and impairs glucose metabolism. We hypothesise that food intake during night shifts may contribute to this phenomenon.

methodsThis open-label, multi-arm, single-site, parallel-group controlled trial involved a 6 day stay at the University of South Australia's sleep laboratory (Adelaide, SA, Australia). Healthy, non-shift-working adults without obesity (N=55; age 24.5 ± 4.8 years; BMI 24.8 ± 2.8 kg/m

resultsNight-shift work impaired insulin sensitivity, as measured by insulin AUC (p=0.035) and the insulin sensitivity index (p=0.016) across all conditions. Insulin secretion, as measured by the insulinogenic index, was increased in the fasting-at-night condition only (p=0.030), resulting in a day×condition interaction in glucose AUC (p<0.001) such that glucose tolerance was impaired in the meal-at night (+2.00 [95% CI 1.45, 2.56], p<0.001) and snack at-night (+0.96 [0.36, 1.56], p=0.022) conditions vs the fasting-at-night (+0.34 [-0.21, 0.89]) condition. A day×condition interaction was also observed in NEFA AUC (p<0.001), being higher in the meal-at-night (+0.07 [0.03, 0.10]. p=0.001) and snack-at-night (0.01 [-0.03, 0.05], p=0.045) conditions vs the fasting-at-night condition (-0.02 [-0.06, 0.01]). No adverse events occurred. CONCLUSIONS/

interpretationThe timing of food intake has a critical effect on glucose metabolism during simulated night-shift work, which was readily amendable to a meal re-timing intervention.

trial registrationAustralian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12616001556437

fundingThis work was funded by the National Health and Medical Research Council (NHMRC), APP1099077.

Indexed as

Blood GlucoseFastingShift Work ScheduleAdultCircadian RhythmFemaleGlucose Tolerance TestHumansInsulinInsulin ResistanceMaleYoung AdultBlood GlucoseInsulinGlucose metabolismMeal sizeMeal timingObesityShift workTime-restricted eatingType 2 diabetes

Identifiers

PMID39422718
PMCPMC11663163

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.