Evidence map›Paper›PMID 39422657›Full record

ArticleCritical care explorations2024

Ultra-Low-Field Portable MRI and Extracorporeal Membrane Oxygenation: Preclinical Safety Testing.

Jin Kook Kang, Eric Etchill, Kate Verdi, Ana K Velez, Sean Kearney, Jeffrey Dodd-O, Errol Bush, Samantha By, Eddy Boskamp, Christopher Wilcox and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care explorations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jin Kook KangDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.ORCID 0000-0003-3631-2789
Eric EtchillDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.
Kate VerdiDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.
Ana K VelezDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.
Sean KearneyDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.
Jeffrey Dodd-ODivision of Cardiac Anesthesiology, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Errol BushDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.
Samantha ByHyperfine, Inc., Guilford, CT.
Eddy BoskampHyperfine, Inc., Guilford, CT.
Christopher WilcoxDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.
Chun Woo ChoiDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.
Bo Soo KimDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.
Glenn J R WhitmanDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.
Sung-Min ChoDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.ORCID 0000-0002-5132-0958

Funding

CLots and Oxygen in Va-ExtracorpoReal membrane oxygenation (CLOVER) studyK23HL157610 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Sung-Min Cho · 2022 to 2026
$797k
NHLBI NIH HHS K23 HL157610
6 · The paper itself

Abstract

contextConventional MRI is incompatible with extracorporeal membrane oxygenation (ECMO) cannulas and pumps. Ultra-low-field portable MRI (ULF-pMRI) with 0.064 Tesla may provide a solution, but its safety and compatibility is unknown. HYPOTHESIS: ULF-pMRI does not cause significant displacement and heating of ECMO cannulas and does not affect ECMO pump function. METHODS AND MODELS: ECMO cannulas in various sizes were tested ex vivo using phantom models to assess displacement force and heating according to the American Society for Testing and Materials criteria. ECMO pump function was assessed by pump flow and power consumption. In vivo studies involved five female domestic pigs (20-42 kg) undergoing different ECMO configurations (peripheral and central cannulation) and types of cannulas with an imaging protocol consisting of T2-weighted, T1-weighted, FLuid-Attenuated Inversion Recovery, and diffusion-weighted imaging sequences.

resultsPhantom models demonstrated that ECMO cannulas, both single lumen with various sizes (15-24-Fr) and double lumen cannula, had average displacement force less than gravitational force within 5 gauss safety line of ULF-pMRI and temperature changes less than 1°C over 15 minutes of scanning and ECMO pump maintained stable flow and power consumption immediately outside of the 5 gauss line. All pig models showed no visible motion due to displacement force or heating of the cannulas. ECMO flow and the animals' hemodynamic status maintained stability, with no changes greater than 10%, respectively. INTERPRETATION AND

conclusionsULF-pMRI is safe and feasible for use with standard ECMO configurations, supporting its clinical application as a neuroimaging modality in ECMO patients.

Indexed as

Extracorporeal Membrane OxygenationMagnetic Resonance ImagingAnimalsCannulaEquipment DesignFemalePhantoms, ImagingSwine

Identifiers

PMID39422657
PMCPMC11495706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.