Evidence map›Paper›PMID 39422467›Full record

ArticlemBio2024

Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of

Elisa Ramos-Sevillano, Giuseppe Ercoli, Modupeh Betts, José Afonso Guerra-Assunção, Amy Iverson, Matthew Frank, Frederick Partridge, Stephanie W Lo, Vitor E Fernandes, Fauzy Nasher and 7 more

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Identification ofJournal of proteome research · 2025
    Article
  6. Transcriptomic analysis ofMicrobial genomics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Elisa Ramos-SevillanoCentre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College London, Rayne Institute, London, United Kingdom.ORCID 0000-0003-0803-2755
Giuseppe ErcoliCentre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College London, Rayne Institute, London, United Kingdom.
Modupeh BettsResearch Department of Infection, Division of Infection and Immunity, University College London, Rayne Institute, London, United Kingdom.ORCID 0000-0003-0083-7487
José Afonso Guerra-AssunçãoGreat Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom.
Amy IversonDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Matthew FrankDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Frederick PartridgeCentre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College London, Rayne Institute, London, United Kingdom.
Stephanie W LoParasites and Microbes, Wellcome Sanger Institute, Hinxton, United Kingdom.ORCID 0000-0002-2182-0222
Vitor E FernandesFaculdade de Medicina e Ciências Biomédicas and ABC-RI. Faro, Faro, Portugal.
Fauzy NasherFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.ORCID 0000-0001-7368-3867
Emma WallCentre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College London, Rayne Institute, London, United Kingdom.
Brendan WrenFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.ORCID 0000-0002-6140-9489
Stephen B GordonMalawi-Liverpool-Wellcome Trust Clinical Research Programme Blantyre, Blantyre, Malawi.
Daniela M FerreiraLiverpool School of Tropical Medicine, Liverpool, United Kingdom.
Rob HeydermanResearch Department of Infection, Division of Infection and Immunity, University College London, Rayne Institute, London, United Kingdom.
Jason RoschDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-1798-1760
Jeremy S BrownCentre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College London, Rayne Institute, London, United Kingdom.ORCID 0000-0002-5650-5361

Funding

Drug resistance enablers and their role in antibiotic treatment failureU19AI158076 · NIAID · BROAD INSTITUTE, INC. · PI COOPER, VAUGHN, ISBERG, RALPH R. · 2022 to 2025
$10.0M
NIAID NIH HHS U19 AI158076NIHR | University College London Hospitals Biomedical Research Centre (UCLH BRC)UKRI | Medical Research Council (MRC) MR/R001871/1UKRI | Medical Research Council (MRC) R/N02687X/1
6 · The paper itself

Abstract

Virulence screens have indicated potential roles during

Indexed as

CarbonMetabolic Networks and PathwaysPneumococcal InfectionsProlineStreptococcus pneumoniaeAnimalsBacterial ProteinsDisease Models, AnimalFemaleGene Expression Regulation, BacterialHumansMiceNasopharynxOxidative StressSepsisVirulenceBacterial ProteinsCarbonProlineformate-tetrahydrofolate ligaseproline synthesisStreptococcus pneumoniaestringent responsevirulence

Identifiers

PMID39422467
PMCPMC11559097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.