Evidence map›Paper›PMID 39422455›Full record

ArticleInternational journal of urology : official journal of the Japanese Urological Association2025

Clinical manifestations of interstitial cystitis and bladder pain syndrome: Analysis of a patient registry in Japan.

Aya Niimi, Yoshiyuki Akiyama, Yamanishi Tomonori, Akira Furuta, Tomohiro Matsuo, Hikaru Tomoe, Hidehiro Kakizaki, Yoshihisa Matsukawa, Teruyuki Ogawa, Takahiko Mitsui and 8 more

Erratum issuedAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of urology : official journal of the Japanese Urological Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Aya NiimiDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yoshiyuki AkiyamaDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yamanishi TomonoriContinence Center, Dokkyo Medical University Hospital, Utsumomiya, Tochigi, Japan.
Akira FurutaDepartment of Urology, Jikei University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0001-7426-6395
Tomohiro MatsuoDepartment of Urology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan.ORCID https://orcid.org/0000-0002-9508-0319
Hikaru TomoeDepartment of Urology, Sayama Sougou Clinic, Sayama, Saitama, Japan.
Hidehiro KakizakiDepartment of Renal and Urologic Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
Yoshihisa MatsukawaDepartment of Urology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.ORCID https://orcid.org/0000-0001-7823-2600
Teruyuki OgawaDepartment of Urology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Takahiko MitsuiDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan.ORCID https://orcid.org/0000-0003-0408-3678
Naoya MasumoriDepartment of Urology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.ORCID https://orcid.org/0000-0001-6324-0739
So InamuraDepartment of Urology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan.
Yutaka EnomotoDivision of Urology, Mitsui Memorial Hospital, Tokyo, Japan.
Akira NomiyaDepartment of Urology, Japan Labour Health and Welfare Organization Kanto Rosai Hospital, Kawasaki, Kanagawa, Japan.
Daichi MaedaDepartment of Molecular and Cellular Pathology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Yasuhiko IgawaDepartment of Urology, Nagano Prefectural Shinshu Medical Center, Suzaka, Nagano, Japan.
Haruki KumeDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yukio HommaDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe clinical manifestations of patients with interstitial cystitis and bladder pain syndrome (IC/BPS) using a patient registry in Japan.

methodsThis retrospective cohort study utilized a patient registry supported by the Japanese Ministry of Health, Labor, and Welfare. Patients were classified as IC or BPS based on cystoscopic findings. Data on demographics, comorbidities, symptom severity, pain intensity, and bladder function were collected and we evaluated the differences in clinical characteristics between IC and BPS, and used multivariate analysis to search for additional factors that might contribute to pain.

resultA data set comprising 529 patients was obtained from 14 university hospitals. 66.5% of the cases were classified as IC and 33.5% as BPS. IC patients were significantly aged and female-dominant. Comorbidities such as autoimmune diseases were more prevalent in IC patients. All of the symptom severity, quality of life impairment, and bladder function were significantly worse in patients with IC. Urinary frequency and maximum voided volume on the Frequency-volume chart were 18.8 times and 15.0 times, and 160.9 and 214.1 mL, respectively. Bladder capacity under anesthesia was 293.8 and 472.6 mL, respectively. Maximum voided volume and the number of Hunner lesions were significant predictors of pain in IC patients.

conclusionThe analysis revealed clinical manifestations of IC/BPS using the largest cohort in Japan. The results indicated higher age, higher female proportion, and higher symptomatic and functional severity in IC patients compared to BPS.

Indexed as

Cystitis, InterstitialAdultAgedAged, 80 and overComorbidityCystoscopyFemaleHumansJapanMaleMiddle AgedQuality of LifeRegistriesRetrospective StudiesSeverity of Illness IndexUrinary Bladderbladder pain syndromeHunner lesioninterstitial cystitispatient registry

Identifiers

PMID39422455
PMCPMC11730405

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.